Intratumor Cisplatin Nephrotoxicity in Combined Laser-Induced Thermal Therapy for Cancer Treatment

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dc.citation.issue8
dc.citation.volume49
dc.contributor.authorPalumbo, Marcel N. [UNIFESP]
dc.contributor.authorCervantes, Onivaldo [UNIFESP]
dc.contributor.authorEugenio, Cecilia [UNIFESP]
dc.contributor.authorHortense, Flavia T. P. [UNIFESP]
dc.contributor.authorRibeiro, Joao C. [UNIFESP]
dc.contributor.authorPaolini, Ana Amelia P.
dc.contributor.authorTedesco, Antonio C.
dc.contributor.authorSercarz, Joel A.
dc.contributor.authorPaiva, Marcos B. [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-08-04T13:40:09Z
dc.date.available2020-08-04T13:40:09Z
dc.date.issued2017
dc.description.abstractIntroduction: Thermal ablation of tumors by Nd:YAG laser has been growing as a multidisciplinary subspecialty defined as laser-induced thermal therapy (LITT), and has been increasingly accepted as a minimally invasive method for palliation of advanced or recurrent cancer. Previous studies have shown that adjuvant chemotherapy can potentiate laser thermal ablation of tumors leading to improved palliation in advanced cancer patients. Objective: Evaluate nephrotoxicity by early markers of renal function in treating head and neck cancer using intra-tumor injections of cisplatin combined with laser-induced thermal therapy CDDP-LITT). Methods: Nine patients with recurrent head and neck tumors were treated by CDDP-LITT in order to determine nephrotoxicity related to this synergistic association. Among the tests requested to detect early were creatinine, magnesium, creatinine clearance, serum urea-BUN, type I urine, and proteinuria at 24 hours. Results: Twelve recurrent tumors in nine patients were treated by CDDP-LITT. Pain was the major complaint four patients), while other symptoms included dysphagia, dyspnea, bleeding, and difficulties in chewing. Fifteen laser procedures were performed and maximal CDDP dose was 50mg. None of the markers for nephrotoxicity showed changes at these levels of CDDP intra-tumor injections. Conclusion: This initial experience with (CDDP-LITT) indicates both safety and therapeutic potential for palliation of advanced head and neck cancer. However, safety and feasibility must be confirmed by longer follow up and further escalation of CDDP doses in a Phase I study to determine maximum tolerated dose (MTD) and demonstrate tangible benefits for patients. (C) 2017 Wiley Periodicals, Inc.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Otolaryngol & Head & Neck Surg, Sao Paulo, Brazil
dc.description.affiliationLos Angeles Sinus & Allergy Inst, Los Angeles, CA USA
dc.description.affiliationUniv Sao Paulo, Fac Philosophy Sci & Letters, Dept Chem, Lab Photobiol & Photomed, Sao Paulo, Brazil|Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Otolaryngol & Head & Neck Surg, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipDepartment of Head and Neck Surgery, the Jonsson Comprehensive Cancer Center
dc.description.sponsorshipDavid Geffen School of Medicine at UCLA
dc.description.sponsorshipNational Institute of Health, National Cancer Institute
dc.description.sponsorshipOffice of Extramural Research, National Institutes of Health
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipIDFAPESP: 08-54714
dc.format.extent756-762
dc.identifierhttp://dx.doi.org/10.1002/lsm.22685
dc.identifier.citationLasers In Surgery And Medicine. Hoboken, v. 49, n. 8, p. 756-762, 2017.
dc.identifier.doi10.1002/lsm.22685
dc.identifier.issn0196-8092
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57325
dc.identifier.wosWOS:000411028000004
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofLasers In Surgery And Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectcisplatinen
dc.subjectlaser-induced thermal therapyen
dc.subjectrecurrent/advanced head and neck canceren
dc.subjectNd:YAG laseren
dc.subjectnephrotoxicityen
dc.titleIntratumor Cisplatin Nephrotoxicity in Combined Laser-Induced Thermal Therapy for Cancer Treatmenten
dc.typeinfo:eu-repo/semantics/article
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