Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats

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dc.contributor.authorOgihara, Cristiana Akemi [UNIFESP]
dc.contributor.authorSchoorlemmer, Gerhardus Hermanus Maria [UNIFESP]
dc.contributor.authorLazari, Maria de Fatima Magalhaes [UNIFESP]
dc.contributor.authorGiannocco, Gisele
dc.contributor.authorLopes, Oswaldo Ubriaco [UNIFESP]
dc.contributor.authorColombari, Eduardo
dc.contributor.authorSato, Monica Akemi
dc.contributor.institutionFMABC
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSão Paulo State Univ UNESP
dc.date.accessioned2016-01-24T14:34:56Z
dc.date.available2016-01-24T14:34:56Z
dc.date.issued2014-01-01
dc.description.abstractExercise training reduces sympathetic activity in hypertensive humans and rats. We hypothesized that the swimming exercisewould change the neurotransmission in the rostral ventrolateral medulla (RVLM), a key region involved in sympathetic outflow, and hemodynamic control in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. Bilateral injections of kynurenic acid (KYN) were carried out in the RVLM in sedentary- (S-) or exercised- (E-) SHR and WKY rats submitted to swimming for 6 weeks. Rats were alpha-chloralose anesthetized and artificially ventilated, with Doppler flow probes around the lower abdominal aorta and superior mesenteric artery. Injections into the RVLM were made before and after i.v. L-NAME (nitric oxide synthase, NOS, inhibitor). Injections of KYN into the RVLM elicited a major vasodilation in the hindlimbmore than in the mesenteric artery in E-SHR compared to S-SHR, but similar decrease in arterial pressure was observed in both groups. Injections of KYN into the RVLM after i.v. L-NAME attenuated the hindlimb vasodilation evoked by KYN and increased the mesenteric vasodilation in ESHR. Swimming exercise can enhance the hindlimb vasodilation mediated by peripheral NO release, reducing the activation of neurons with EAA receptors in the RVLM in SHR.en
dc.description.affiliationFMABC, Dept Physiol, BR-09060650 Santo Andre, SP, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Physiol, BR-04023901 São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Pharmacol, BR-04044020 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Sch Dent, Dept Pathol & Physiol, BR-14801385 Araraquara, SP, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Physiol, BR-04023901 São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Pharmacol, BR-04044020 São Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2016-01-24T14:34:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-01-01. Added 1 bitstream(s) on 2016-01-31T13:37:52Z : No. of bitstreams: 1 WOS000332283900001.pdf: 1891175 bytes, checksum: acf65d4de5449a972a289a59daf8be9c (MD5)en
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipNucleo de Estudo Pesquisa e Assessoria a Pesquisa da Faculdade de Medicina do ABC (NEPAS, FMABC)pt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipIDFAPESP: 06/60842-1pt
dc.format.extent9
dc.identifierhttps://dx.doi.org/10.1155/2014/487129
dc.identifier.citationBiomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2014.
dc.identifier.doi10.1155/2014/487129
dc.identifier.fileWOS000332283900001.pdf
dc.identifier.issn2314-6133
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37139
dc.identifier.wosWOS:000332283900001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofBiomed Research International
dc.rightsAcesso aberto
dc.titleSwimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Ratsen
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