Image evaluation of HIV encephalopathy: a multimodal approach using quantitative MR techniques
| dc.contributor.author | Prado, Paulo T. C. | |
| dc.contributor.author | Escorsi-Rosset, Sara | |
| dc.contributor.author | Cervi, Maria C. | |
| dc.contributor.author | Santos, Antonio Carlos | |
| dc.contributor.institution | Universidade de São Paulo (USP) | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2016-01-24T14:17:22Z | |
| dc.date.available | 2016-01-24T14:17:22Z | |
| dc.date.issued | 2011-11-01 | |
| dc.description.abstract | Introduction A multimodal approach of the human immunodeficiency virus (HIV) encephalopathy using quantitative magnetic resonance (MR) techniques can demonstrate brain changes not detectable only with conventional magnetic resonance imaging (MRI). the aim of this study was to compare conventional MRI and MR quantitative techniques, such as magnetic resonance spectroscopy (MRS) and relaxometry and to determine whether quantitative techniques are more sensitive than conventional imaging for brain changes caused by HIV infection.Methods We studied prospectively nine HIV positive children (mean age 6 years, from 5 to 8 years old) and nine controls (mean age 7.3 years; from 3 to 10 years), using MRS and relaxometry. Examinations were carried on 1.5-T equipment.Results HIV-positive patients presented with only minor findings and all control patients had normal conventional MR findings. MRS findings showed an increase in choline to creatine (CHO/CRE) ratios bilaterally in both frontal gray and white matter, in the left parietal white matter, and in total CHO/CRE ratio. in contrast, N-acetylaspartate to creatine (NAA/CRE) ratios did not present with any significant difference between both groups. Relaxometry showed significant bilateral abnormalities, with lengthening of the relaxation time in HIV positive in many regions.Conclusion Conventional MRI is not sensitive for early brain changes caused by HIV infection. Quantitative techniques such as MRS and relaxometry appear as valuable tools in the diagnosis of these early changes. Therefore, a multimodal quantitative study can be useful in demonstrating and understanding the physiopathology of the disease. | en |
| dc.description.affiliation | Hosp Clin FMRP USP, BR-14048900 Ribeirao Preto, SP, Brazil | |
| dc.description.affiliation | Univ São Paulo, Ribeirao Preto Sch Med, Radiol Sect, Dept Internal Med, São Paulo, Brazil | |
| dc.description.affiliation | Univ São Paulo, Ribeirao Preto Sch Med, Dept Pediat, São Paulo, Brazil | |
| dc.description.source | Web of Science | |
| dc.format.extent | 899-908 | |
| dc.identifier | http://dx.doi.org/10.1007/s00234-011-0869-8 | |
| dc.identifier.citation | Neuroradiology. New York: Springer, v. 53, n. 11, p. 899-908, 2011. | |
| dc.identifier.doi | 10.1007/s00234-011-0869-8 | |
| dc.identifier.issn | 0028-3940 | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/34180 | |
| dc.identifier.wos | WOS:000297163500009 | |
| dc.language.iso | eng | |
| dc.publisher | Springer | |
| dc.relation.ispartof | Neuroradiology | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.license | http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 | |
| dc.subject | Quantitative MR techniques | en |
| dc.subject | MRS | en |
| dc.subject | Spectroscopy | en |
| dc.subject | Relaxometry | en |
| dc.subject | HIV encephalopathy | en |
| dc.title | Image evaluation of HIV encephalopathy: a multimodal approach using quantitative MR techniques | en |
| dc.type | info:eu-repo/semantics/article |