Digitoxin Prolongs Survival of Female Rats With Heart Failure Due to Large Myocardial Infarction

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dc.contributor.authorHelber, Izo [UNIFESP]
dc.contributor.authorDos Santos, Alexandra A. [UNIFESP]
dc.contributor.authorAntonio, Ednei L. [UNIFESP]
dc.contributor.authorFlumignan, Ronald L. G. [UNIFESP]
dc.contributor.authorBocalini, Danilo S. [UNIFESP]
dc.contributor.authorPiccolo, Camila [UNIFESP]
dc.contributor.authorGheorghiade, Mihai
dc.contributor.authorTucci, Paulo J. F. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionNorthwestern Univ
dc.date.accessioned2016-01-24T13:58:50Z
dc.date.available2016-01-24T13:58:50Z
dc.date.issued2009-11-01
dc.description.abstractBackground: We analyzed whether digitoxin affects the survival of rats with congestive heart failure.Methods and Results: the influence of digitoxin (0.1 mg. 100 g.day, orally) on the survival of infarcted female rats (n = 170) randomized as Control Infarcted (CI, n = 85) or Digitoxin (D, n = 85) was evaluated for 280 days. Mean Survival was 235 +/- 7 days for CI and 255 +/- 5 days for D (log-rank test: P = .0602). Digitoxin did not affect survival in rats with congestive heart failure from myocardial infarction <40% of the left ventricle, but did prolong survival in rats with infarction >= 40%. the log-rank test defined higher mortality (P = .0161) in CI > 40% (56%) than in D > 40% (34%), with a hazard ratio of 2.03. Pulmonary water content and papillary muscle mechanics were analyzed in CI (n = 7) and D (n = 14) survivors. Significant differences were observed regarding pulmonary water content (CI: 82 +/- 0.3; D: 80 +/- 0.3%; P = .0014), developed tension (CI: 2.7 +/- 0.3; D: 3.8 +/- 0.3 g/mm(2); P = .0286) and +dT/dt (CI: 24 +/- 3; D: 39 4 mg mm(2). s; P = .0109).Conclusion: in conclusion, long-term digitoxin administration reduced cardiac impairment after myocardium infarction, attenuated myocardial dysfunction, reduced pulmonary congestion, and provided the first evidence regarding the efficiency of digitoxin in prolonging survival in experimental cardiac failure. (I Cardiac Fail 2009;15.-798-804)en
dc.description.affiliationUniversidade Federal de São Paulo, Cardiac Physiol & Physiopathol Lab, São Paulo, Brazil
dc.description.affiliationNorthwestern Univ, Chicago, IL 60611 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Cardiac Physiol & Physiopathol Lab, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent798-804
dc.identifierhttp://dx.doi.org/10.1016/j.cardfail.2009.05.002
dc.identifier.citationJournal of Cardiac Failure. Philadelphia: Churchill Livingstone Inc Medical Publishers, v. 15, n. 9, p. 798-804, 2009.
dc.identifier.doi10.1016/j.cardfail.2009.05.002
dc.identifier.issn1071-9164
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31895
dc.identifier.wosWOS:000271776400011
dc.language.isoeng
dc.publisherChurchill Livingstone Inc Medical Publishers
dc.relation.ispartofJournal of Cardiac Failure
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPsychologicalen
dc.subjectsurvivalen
dc.titleDigitoxin Prolongs Survival of Female Rats With Heart Failure Due to Large Myocardial Infarctionen
dc.typeinfo:eu-repo/semantics/article
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