Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats
| dc.contributor.author | Mello, LEAM | |
| dc.contributor.author | Kohman, C. M. | |
| dc.contributor.author | Tan, A. M. | |
| dc.contributor.author | Cavalheiro, E. A. | |
| dc.contributor.author | Finch, D. M. | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.contributor.institution | UNIV CALIF LOS ANGELES | |
| dc.date.accessioned | 2016-01-24T11:40:31Z | |
| dc.date.available | 2016-01-24T11:40:31Z | |
| dc.date.issued | 1996-04-19 | |
| dc.description.abstract | Acute seizures and status epilepticus induced by pilocarpine lead to the expression of Fos-like immunoreactivity in several specific brain areas in a manner similar to that of other models of limbic seizures. Upon development of status epilepticus after systemic pilocarpine injection, animals develop a state where chronic spontaneous seizures recur. Assessment of Fos-like immunoreactivity after such spontaneous seizures or after status epilepticus reinduction reveals either lack of staining or a weak reaction in a few brain areas including the ventral tip of the dentate gyrus, prepiriform, lateral piriform and perirhinal cortices, and scattered locations throughout temporal neocortex. Our results suggest that status epiiepticus induction may lead to a long-lasting state of Fos down-regulation. | en |
| dc.description.affiliation | UNIFESP,ESCOLA PAULISTA MED,DEPT NEUROL,BR-04023900 São Paulo,BRAZIL | |
| dc.description.affiliation | UNIV CALIF LOS ANGELES,DEPT NEUROL,LOS ANGELES,CA 90024 | |
| dc.description.affiliation | UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA 90024 | |
| dc.description.affiliationUnifesp | UNIFESP,ESCOLA PAULISTA MED,DEPT NEUROL,BR-04023900 São Paulo,BRAZIL | |
| dc.description.source | Web of Science | |
| dc.format.extent | 133-137 | |
| dc.identifier | http://dx.doi.org/10.1016/0304-3940(96)12562-3 | |
| dc.identifier.citation | Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 208, n. 2, p. 133-137, 1996. | |
| dc.identifier.doi | 10.1016/0304-3940(96)12562-3 | |
| dc.identifier.issn | 0304-3940 | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/25580 | |
| dc.identifier.wos | WOS:A1996UH10800016 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier B.V. | |
| dc.relation.ispartof | Neuroscience Letters | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
| dc.subject | epilepsy | en |
| dc.subject | neuronal plasticity | en |
| dc.subject | epileptogenesis | en |
| dc.subject | temporal lobe | en |
| dc.subject | hippocampus | en |
| dc.subject | entorhinal cortex | en |
| dc.subject | prepiriform cortex | en |
| dc.subject | pilocarpine | en |
| dc.title | Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats | en |
| dc.type | info:eu-repo/semantics/article |