Effects of Zolpidem CR on Sleep and Nocturnal Ventilation in Patients with Heart Failure

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dc.citation.issue8
dc.citation.volume39
dc.contributor.authorGatti, Rodrigo Castiglia [UNIFESP]
dc.contributor.authorBurke, Patrick Rademaker [UNIFESP]
dc.contributor.authorOtuyama, Leonardo Jun [UNIFESP]
dc.contributor.authorAlmeida, Dirceu Rodrigues de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorPoyares, Dalva [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageWestchester
dc.date.accessioned2020-08-14T13:44:01Z
dc.date.available2020-08-14T13:44:01Z
dc.date.issued2016
dc.description.abstractStudy Objective: This study aimed to evaluate the effects of zolpidem CR (controlled release) on sleep and nocturnal ventilation in patients with congestive heart failure, a population at risk for insomnia and poor sleep quality. Methods: Fifteen patients with heart failure (ischemic cardiomyopathy) and ejection fraction ≤ 45% in NYHA functional class I or II were evaluated with full polysomnography in a placebo-controlled, double-blind, randomized trial. Patients underwent three tests: (1) baseline polysomnography and, after randomization, (2) a new test with zolpidem CR 12.5 mg or placebo, and after 1 week, (3) a new polysomnography, crossing the “medication” used. Results: A 16% increase in total sleep time was found with the use of zolpidem CR and an increase in stage 3 NREM sleep (slow wave sleep). The apnea hypopnea index (AHI) did not change with zolpidem CR even after controlling for supine position; however, a slight but significant decrease was observed in lowest oxygen saturation compared with baseline and placebo conditions (83.60 ± 5.51; 84.43 ± 3.80; 80.71 ± 5.18, P = 0.002). Conclusion: Zolpidem CR improved sleep structure in patients with heart failure, did not change apnea hypopnea index, but slightly decreased lowest oxygen saturation.en
dc.description.affiliationUniv Fed Sao Paulo, Sleep Div, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Cardiol, Dept Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sleep Div, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Cardiol, Dept Med, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociação Fundo Incentivo a Pesquisa (AFIP), São Paulo, Brazil
dc.format.extent1501-1505
dc.identifierhttps://dx.doi.org/10.5665/sleep.6006
dc.identifier.citationSleep. Westchester, v. 39, n. 8, p. 1501-1505, 2016.
dc.identifier.doi10.5665/sleep.6006
dc.identifier.fileWOS000381746800004.pdf
dc.identifier.issn0161-8105
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57488
dc.identifier.wosWOS:000381746800004
dc.language.isoeng
dc.publisherAmer Acad Sleep Medicine
dc.relation.ispartofSleep
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHeart failureen
dc.subjectPolysomnographyen
dc.subjectZolpidem CRen
dc.subjectSleepen
dc.titleEffects of Zolpidem CR on Sleep and Nocturnal Ventilation in Patients with Heart Failureen
dc.typeinfo:eu-repo/semantics/article
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