Multiple sclerosis risk perception and acceptance for Brazilian patients

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dc.citation.issue1
dc.citation.volume76
dc.contributor.authorBichuetti, Denis Bernardi
dc.contributor.authorFranco, Carolina Azze
dc.contributor.authorElias, Isaac
dc.contributor.authorMendonca, Andreia C. R.
dc.contributor.authorDiniz Carvalho, Lorraine Fiama
dc.contributor.authorDiniz, Denise Sisterolli
dc.contributor.authorTur, Carmen
dc.contributor.authorTintore, Mar
dc.contributor.authorLobato de Oliveira, Enedina Maria
dc.coverageSao Paulo Sp
dc.date.accessioned2020-07-02T18:52:09Z
dc.date.available2020-07-02T18:52:09Z
dc.date.issued2018
dc.description.abstractThe perception of multiple sclerosis (MS) severity and risk associated with therapies might influence shared decision making in different countries. We investigated the perception of MS severity and factors associated with risk acceptance in Brazil in 96 patients with relapsing-remitting MS using a standardized questionnaire and compared this with two European cohorts. Multiple sclerosis was perceived as a very severe disease and the risk of developing progressive multifocal leukoencephalopathy due to natalizumab was seen as moderate to high. Seventy-six percent considered a risk of 1:1,000, or higher, an impediment for natalizumab use. Older age was the only variable associated with higher risk acceptance and our patients showed a more conservative profile than German and Spanish patients. Our patients perceived MS severity and progressive multifocal leukoencephalopathy risk similarly to elsewhere, but their willingness to take risks was more conservative. This should be considered when discussing therapeutic options and it might have an impact on guideline adaptations.en
dc.description.affiliationUniv Fed Sao Paulo, Disciplina Neurol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Goias, Fac Estacio Sa Goias, Ctr Referencia & Invest Esclerose Multipla, Goiania, Go, Brazil
dc.description.affiliationUniv Fed Goias, Ctr Referencia & Invest Esclerose Multipla, Goiania, Go, Brazil
dc.description.affiliationUniv Autonoma Barcelona, Hosp Univ ValldHebron, Ctr Catalonia, Dept Neurol Neuroimmunol & Multiple Sclerosis, Barcelona, Spain
dc.description.affiliationUCL, Inst Neurol, Dept Neuroinflammat, London, England
dc.description.affiliationUnifespUniv Fed Sao Paulo, Disciplina Neurol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent6-12
dc.identifierhttp://dx.doi.org/10.1590/0004-282X20170167
dc.identifier.citationArquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 76, n. 1, p. 6-12, 2018.
dc.identifier.doi10.1590/0004-282X20170167
dc.identifier.fileWOS000422938800003.pdf
dc.identifier.issn0004-282X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53910
dc.identifier.wosWOS:000422938800003
dc.language.isoeng
dc.publisherAssoc Arquivos Neuro- Psiquiatria
dc.relation.ispartofArquivos De Neuro-Psiquiatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmultiple sclerosisen
dc.subjectnatalizumaben
dc.subjectrisk-takingen
dc.subjectrisk assessmenten
dc.subjectdecision makingen
dc.titleMultiple sclerosis risk perception and acceptance for Brazilian patientsen
dc.typeinfo:eu-repo/semantics/article
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