Hepatocellular carcinoma in association with bile duct hamartomas: report on 2 cases and review of the literature

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dc.contributor.authorHeinke, Thais [UNIFESP]
dc.contributor.authorPellacani, Lucila Bohme [UNIFESP]
dc.contributor.authorOliveira Costa, Henrique de [UNIFESP]
dc.contributor.authorFuziy, Rogerio Aoki [UNIFESP]
dc.contributor.authorFranco, Marcello [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:25Z
dc.date.available2016-01-24T13:51:25Z
dc.date.issued2008-06-01
dc.description.abstractBiliary hamartomas are hepatic lesions related to defects in the ductal plate and are part of the spectrum of adult polycystic disease. Microscopically, the lesions are small and consist of irregular bile ducts amidst a fibrous stroma. There are reports on the malignant transformation of biliary hamartomas, particularly on cholangiocarcinoma. Case 1: a 19-year-old woman presented with increased abdominal volume, lumbar pain, jaundice, choluria, cachexia, and progression to hepatic insufficiency. At autopsy, the liver weighed 8850 g and showed a 20.5-cm mass in the right lobe and nodules in the left lobe. Case 2: a 39-year-old man presented with an asymptomatic nodule in the right hepatic lobe. A 6.5-cm liver segment containing a 3.0-cm nodule was excised. Histopathology of both cases revealed hepatocelluar carcinoma associated with multiple bile duct hamartomas (von Meyenburg complex). Bile duct hamartoma is generally and incidental finding at laparotomy and autopsy because its course is asymptomatic. the literature has documented its possible progression to malignant neoplasia. However, this relationship has only been established with cholangiocarcinomas. We report herein for the first time on the association of the lesion with hepatocellular carcinoma. (C) 2008 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, EPM, Dept Patol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Dept Patol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent208-211
dc.identifierhttp://dx.doi.org/10.1016/j.anndiagpath.2006.12.003
dc.identifier.citationAnnals of Diagnostic Pathology. New York: Elsevier B.V., v. 12, n. 3, p. 208-211, 2008.
dc.identifier.doi10.1016/j.anndiagpath.2006.12.003
dc.identifier.issn1092-9134
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30694
dc.identifier.wosWOS:000256390200009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAnnals of Diagnostic Pathology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectbile duct hamartomaen
dc.subjectliver cell carcinomaen
dc.subjecthepatocellular carcinomaen
dc.titleHepatocellular carcinoma in association with bile duct hamartomas: report on 2 cases and review of the literatureen
dc.typeinfo:eu-repo/semantics/article
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