Association of complement factor H Y402H polymorphism and age-related macular degeneration in Brazilian patients

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dc.contributor.authorTeixeira, Anderson G. [UNIFESP]
dc.contributor.authorSilva, Aldacilene S.
dc.contributor.authorLin, Fabio L. H.
dc.contributor.authorVelletri, Roberta [UNIFESP]
dc.contributor.authorBavia, Lorena
dc.contributor.authorBelfort, Rubens Junior [UNIFESP]
dc.contributor.authorIsaac, Lourdes
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:05:14Z
dc.date.available2016-01-24T14:05:14Z
dc.date.issued2010-08-01
dc.description.abstractPurpose:The aim of this study was investigate the association between complement Factor H polymorphism (Y402H) and age-related macular degeneration (AMD) in Brazilian patients.Methods:Patients with AMD aged 50 or more and age-matched healthy controls were enrolled in the study. Genomic DNA was isolated from leucocytes of patients and controls; the Y402H polymorphism of complement Factor H gene (CFH) was determined by polymerase chain reaction directed sequencing.Results:The frequency of 1277C allele of Factor H was 56.30% in patients with AMD compared with 36.51% in controls (p-value = 0.001). the genotypic distribution differed significantly between the two groups (1277CC 36.98%, 1277CT 38.65% and 1277TT 24.37% for AMD group; 1277CC 13.16%, 1277CT 46.71% and 1277TT 40.13% for controls, p-value = 0.001). the odds ratio for patients with AMD carrying only one 1277C allele was 1.36 and for those carrying two 1277C alleles was 4.63, when compared to the control group.Conclusions:These results suggest the Y402H polymorphism of CFH is a risk factor to the development of AMD in Brazilian patients. This is in accordance with findings from the majority of previous study population in Europe and North American.en
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2006/50990-3
dc.description.sponsorshipIDFAPESP: 06/53296-0
dc.description.sponsorshipIDCNPq: 470069/2007-4
dc.format.extentE165-E169
dc.identifierhttp://dx.doi.org/10.1111/j.1755-3768.2010.01932.x
dc.identifier.citationActa Ophthalmologica. Malden: Wiley-Blackwell, v. 88, n. 5, p. E165-E169, 2010.
dc.identifier.doi10.1111/j.1755-3768.2010.01932.x
dc.identifier.issn1755-375X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32748
dc.identifier.wosWOS:000279898200003
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofActa Ophthalmologica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectage-related macular degenerationen
dc.subjectcomplement Factor H geneen
dc.subjectcomplement systemen
dc.subjectPolymorphismen
dc.titleAssociation of complement factor H Y402H polymorphism and age-related macular degeneration in Brazilian patientsen
dc.typeinfo:eu-repo/semantics/article
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