Mild acute stress reactivates memory of a discriminative avoidance task in mice

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dc.contributor.authorTakatsu-Coleman, Andre L. [UNIFESP]
dc.contributor.authorPatti, Camilla L. [UNIFESP]
dc.contributor.authorZanin, Karina A. [UNIFESP]
dc.contributor.authorSanday, Leandro [UNIFESP]
dc.contributor.authorZager, Adriano [UNIFESP]
dc.contributor.authorCarvalho, Rita C. [UNIFESP]
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:45Z
dc.date.available2016-01-24T14:31:45Z
dc.date.issued2013-05-01
dc.description.abstractPrevious studies have demonstrated that stress or glucocorticoids impair the retrieval of spatial memory in rodents and declarative memory in humans. However, the effects on memory retrieval of stress introduced a long time after learning have not been well studied. We investigated whether a mild, extrinsic stressor (1-s 0.1 or 0.3 mA foot shock) would reactivate low baseline retrieval of an aversive memory [the plus-maze discriminative avoidance task (PM-DAT)] and if it would be modulated by glucocorticoids. in Experiment 1, male Swiss mice received pre-test foot shock (n = 10 mice/group) 7 days after training and just before testing. A time-retrieval curve for low baseline retrieval for the subsequent experiments was also determined (Experiment 2, n = 10 mice/group). We investigated if pre-test foot shock could modify corticosterone release (Experiment 3, n = 8-9 mice/group) and reinstate retrieval in the PM-DAT (Experiment 4, n = 15 mice/group). the effects of metyrapone (100 mg/kg) on retrieval reinstatement (Experiment 5, n = 15 mice/group) and serum corticosterone enhancement (Experiments 6, n = 7-9 mice/group) induced by foot shock were analyzed. Finally, the effects of foot shock itself on PM-DAT exploration were verified (Experiment 7, n = 10 mice/group). We demonstrated here that foot shock reinstated the retrieval of a low baseline, discriminative avoidance task 30 (but not 7) days after training. This facilitative effect was not dependent on corticosterone secretion because metyrapone abolished the enhancement of corticosterone concentration but did not reverse the stress-induced reinstatement of retrieval.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipIDFAPESP: 1998/14303-3
dc.format.extent278-288
dc.identifierhttp://dx.doi.org/10.3109/10253890.2012.742058
dc.identifier.citationStress-the International Journal On the Biology of Stress. London: Informa Healthcare, v. 16, n. 3, p. 278-288, 2013.
dc.identifier.doi10.3109/10253890.2012.742058
dc.identifier.issn1025-3890
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36326
dc.identifier.wosWOS:000317486300002
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofStress-the International Journal On the Biology of Stress
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectAnxious behavioren
dc.subjectcorticosteroneen
dc.subjectfoot shocken
dc.subjectmemory recollectionen
dc.subjectmetyraponeen
dc.subjectplus-maze discriminative avoidance tasken
dc.titleMild acute stress reactivates memory of a discriminative avoidance task in miceen
dc.typeinfo:eu-repo/semantics/article
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