Association between demyelinating disease and autoimmune rheumatic disease in a pediatric population

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dc.citation.issue3
dc.citation.volume57
dc.contributor.authorAmorim, Ana Luiza M. [UNIFESP]
dc.contributor.authorCabral, Nadia C. [UNIFESP]
dc.contributor.authorOsaku, Fabiane M. [UNIFESP]
dc.contributor.authorLen, Claudio A. [UNIFESP]
dc.contributor.authorOliveira, Enedina M. L. [UNIFESP]
dc.contributor.authorTerreri, Maria Teresa [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-07-13T11:53:19Z
dc.date.available2020-07-13T11:53:19Z
dc.date.issued2017
dc.description.abstractIntroduction: Multiple sclerosis (MS) and neuromyelitis optica (NMO) are demyelinating diseases of the central nervous system. Autoimmunity in patients with demyelinating disease and in their families has been broadly investigated and discussed. Recent studies show a higher incidence of rheumatic autoimmune diseases among adult patients with MS or NMO and their families, but there are no studies in the pediatric population. Objective: To evaluate an association of MS and NMO with autoimmune rheumatic diseases in pediatric patients. Method: 22 patients younger than 21 years old with MS or NMO diagnosed before the age of 18 years were evaluated regarding epidemiological data, clinical presentation, association with autoimmune diseases, family history of autoimmune diseases, laboratory findings, imaging studies and presence of auto-antibodies. Results: Among the patients studied, there was a prevalence of females (68.1%). The mean age of symptoms onset was 8 years and 9 months and the mean current age was 16 years and 4 months. Two patients (9%) had a history of associated autoimmune rheumatic disease: one case of juvenile dermatomyositis in a patient with NMO and another of systemic lupus erythematosus in a patient with MS. Three patients (13%) had a family history of autoimmunity in first-degree relatives. ANA was found positive in 80% of patients with NMO and 52% of patients with MS. About 15% of ANA-positive patients were diagnosed with rheumatologic autoimmune disieses. Conclusion: Among patients with demyelinating diseases diagnosed in childhood included in this study there was a high frequency of ANA positivity but a lower association with rheumatologic autoimmune diseases than that observed in studies conducted in adults. (C) 2016 Elsevier Editora Ltda.en
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Dept Pediat, Setor Reumatol Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Dept Neurol & Neurocirurgia, Setor Doencas Desmielinizantes, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Dept Pediat, Setor Reumatol Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Dept Neurol & Neurocirurgia, Setor Doencas Desmielinizantes, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent224-228
dc.identifierhttp://dx.doi.org/10.1016/j.rbr.2016.08.004
dc.identifier.citationRevista Brasileira De Reumatologia. New York, v. 57, n. 3, p. 224-228, 2017.
dc.identifier.doi10.1016/j.rbr.2016.08.004
dc.identifier.issn0482-5004
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54536
dc.identifier.wosWOS:000404535600007
dc.language.isopor
dc.publisherElsevier Science Inc
dc.relation.ispartofRevista Brasileira De Reumatologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutoimmune diseasesen
dc.subjectRheumatic diseasesen
dc.subjectDemyelinating diseasesen
dc.subjectChildhooden
dc.titleAssociation between demyelinating disease and autoimmune rheumatic disease in a pediatric populationen
dc.typeinfo:eu-repo/semantics/article
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