Characterization of intracranial pressure behavior in chronic epileptic animals: a preliminary study

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dc.contributor.authorCardim, Danilo Augusto
dc.contributor.authorFrigieri, Gustavo Henrique
dc.contributor.authorTroca Cabella, Brenno Caetano
dc.contributor.authorMalheiros, Jackeline Moraes [UNIFESP]
dc.contributor.authorCardim, Ana Carolina
dc.contributor.authorWang, Charles Chenwei
dc.contributor.authorPacheco Andrade, Rodrigo de Albuquerque
dc.contributor.authorCovolan, Luciene [UNIFESP]
dc.contributor.authorTannus, Alberto
dc.contributor.authorMascarenhas, Sergio
dc.date.accessioned2019-01-21T10:29:40Z
dc.date.available2019-01-21T10:29:40Z
dc.date.issued2016
dc.description.abstractIntracranial pressure (ICP) is a major neurological parameter in animals and humans. ICP is a function of the relationship between the contents of the cranium (brain parenchyma, cerebrospinal fluid, and blood) and the volume of the skull. Increased ICP can cause serious physiological effects or even death in patients who do not quickly receive proper care, which includes ICP monitoring. Epilepsies are a set of central nervous system disorders resulting from abnormal and excessive neuronal discharges, usually associated with hypersynchronism and/or hyperexcitability. Temporal lobe epilepsy (TLE) is one of the most common forms of epilepsy and is also refractory to medication. ICP characteristics of subjects with epilepsy have not been elucidated because there are few studies associating these two important neurological factors. In this work, an invasive (ICPi) and the new minimally invasive (ICPmi) methods were used to evaluate ICP features in rats with chronic epilepsy, induced by the experimental model of pilocarpine, capable of generating the main features of human TLE in these animals.en
dc.description.affiliationFederal University of Sao Carlos, Joint Graduate Program in Physiological Sciences, PIPGCF. Rodovia Washington Luis, km 235Sao Carlos, Sao Paulo Brazil
dc.description.affiliationBaincare Corp.SapraSao Carlos Brazil
dc.description.affiliationDepartment of Physiology Federal University of Sao Paulo Sao Paulo Brazil
dc.description.affiliationPhysics Institute of Sao Carlos University of Sao Paulo Sao Carlos Brazil
dc.description.affiliationUnifespDepartment of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil.
dc.description.sourceWeb of Science
dc.format.extent329-333
dc.identifierhttp://dx.doi.org/10.1007/978-3-319-22533-3_65
dc.identifier.citationIntracranial Pressure And Brain Monitoring Xv. Dordrecht, v. 122, p. 329-333, 2016.
dc.identifier.doi10.1007/978-3-319-22533-3_65
dc.identifier.issn0065-1419
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49318
dc.identifier.wosWOS:000390281000065
dc.language.isoeng
dc.publisherUniv Estadual Oeste Parana-Unioeste
dc.relation.ispartofIntracranial Pressure And Brain Monitoring Xv
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectIntracranial Pressureen
dc.subjectEpilepsyen
dc.subjectIcpen
dc.subjectIcp Monitoringen
dc.subjectPilocarpineTemporal-Lobe Epilepsyen
dc.subjectPilocarpine Modelen
dc.subjectSeizuresen
dc.subjectDamageen
dc.subjectRatsen
dc.titleCharacterization of intracranial pressure behavior in chronic epileptic animals: a preliminary studyen
dc.typeinfo:eu-repo/semantics/conferenceObject
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