Multiple trial inhibitory avoidance acquisition and retrieval are resistant to chronic stress

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dc.citation.volume147
dc.contributor.authorRaya, J. [UNIFESP]
dc.contributor.authorGirardi, C. E. N. [UNIFESP]
dc.contributor.authorEsumi, L. A. [UNIFESP]
dc.contributor.authorFerreira, L. B. T. [UNIFESP]
dc.contributor.authorHipolide, D. C. [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-08T13:09:49Z
dc.date.available2020-07-08T13:09:49Z
dc.date.issued2018
dc.description.abstractChronic mild stress (CMS) is a widely accepted animal model relevant to depression that among other consequences, is chiefly known to induce anhedonia, often assessed as decreased preference for sucrose solution. CMS is also known to affect cognition, particularly memory tasks. In this study we have employed the multiple trial inhibitory avoidance memory task (MTIA) to assess CMS effects on memory acquisition and retrieval. MTIA consists of repeated exposures to the unconditioned stimulus until a learning criterion is reached. Wistar rats underwent CMS for 5 weeks, and sucrose consumption was assessed once a week. At the end of CMS, animals were evaluated in the MTIA task. Overall decreased sucrose solution preference was highly variable. Further analyses showed that a subset of animals expressed resilience while another subset was sensitive to stress. CMS did not affect the number of acquisition sessions before reaching criterion or retrieval latency of MTIA task in neither sensitive nor resilient groups. Although tasks that assess learning ability in animal models relevant to depression indicate cognitive deficits, the ability to learn the association between compartment crossing and the aversive electric foot shock, which is strongly dependent on emotional aspects, was intact.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
dc.description.affiliationUniv Ibirapuera, Programa Posgrad Psicossomat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipIDFAPESP: 2012/00017-8]
dc.description.sponsorshipIDCNPq: 473329/2011-5
dc.format.extent28-32
dc.identifierhttp://dx.doi.org/10.1016/j.beproc.2017.12.008
dc.identifier.citationBehavioural Processes. Amsterdam, v. 147, p. 28-32, 2018.
dc.identifier.doi10.1016/j.beproc.2017.12.008
dc.identifier.issn0376-6357
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54221
dc.identifier.wosWOS:000423645400005
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofBehavioural Processes
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectChronic stressen
dc.subjectSucrose preferenceen
dc.subjectAnhedoniaen
dc.subjectInhibitory avoidanceen
dc.subjectStress sensitivityen
dc.titleMultiple trial inhibitory avoidance acquisition and retrieval are resistant to chronic stressen
dc.typeinfo:eu-repo/semantics/article
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