Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats

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dc.citation.volumev. 9
dc.contributor.authorBuonfiglio, Daniella
dc.contributor.authorParthimos, Rafaela
dc.contributor.authorDantas, Rosana
dc.contributor.authorSilva, Raysa Cerqueira
dc.contributor.authorGomes, Guilherme
dc.contributor.authorAndrade-Silva, Jessica
dc.contributor.authorRamos-Lobo, Angela
dc.contributor.authorAmaral, Fernanda Gaspar [UNIFESP]
dc.contributor.authorMatos, Raphael
dc.contributor.authorSinesio Jr., Jose
dc.contributor.authorMotta-Teixeira, Livia Clemente
dc.contributor.authorDonato Jr., Jose
dc.contributor.authorReiter, Russel J.
dc.contributor.authorCipolla-Neto, Jose
dc.coverageLausanne
dc.date.accessioned2020-07-20T16:31:13Z
dc.date.available2020-07-20T16:31:13Z
dc.date.issued2018
dc.description.abstractMelatonin (Mel), a molecule that conveys photoperiodic information to the organisms, is also involved in the regulation of energy homeostasis. Mechanisms of action of Mel in the energy balance remain unclearen
dc.description.abstractherein we investigated how Mel regulates energy intake and expenditure to promote a proper energy balance. Male Wistar rats were assigned to control, control + Mel, pinealectomized (PINX) and PINX + Mel groups. To restore a 24-h rhythm, Mel (1 mg/kg) was added to the drinking water exclusively during the dark phase for 13 weeks. After this treatment period, rats were subjected to a 24-h fasting test, an acute leptin responsiveness test and cold challenge. Mel treatment reduced food intake, body weight, and adiposity. When challenged to 24-h fasting, Mel-treated rats also showed reduced hyperphagia when the food was replaced. Remarkably, PINX rats exhibited leptin resistanceen
dc.description.abstractthis was likely related to the capacity of leptin to affect body weight, food intake, and hypothalamic signal-transducer and activator of transcription 3 phosphorylation, all of which were reduced. Mel treatment restored leptin sensitivity in PINX rats. An increased hypothalamic expression of agouti-related peptide (Agrp), neuropeptide Y, and Orexin was observed in the PINX group while Mel treatment reduced the expression of Agrp and Orexin. In addition, PINX rats presented lower UCP1 protein levels in the brown adipose tissue and required higher tail vasoconstriction to get a proper thermogenic response to cold challenge. Our findings reveal a previously unrecognized interaction of Mel and leptin in the hypothalamus to regulate the energy balance. These findings may help to explain the high incidence of metabolic diseases in individuals exposed to light at night.en
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci 1, Dept Physiol & Biophys, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sao Carlos Inst Phys IFSC, Dept Phys & Interdisciplinary Sci FCI, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Dept Physiol, Sao Paulo, Brazil
dc.description.affiliationUT Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX USA
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Dept Physiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipCNPq
dc.description.sponsorshipIDFAPESP: 2014/50457-0
dc.description.sponsorshipIDFAPESP: 2015/26190-6
dc.description.sponsorshipIDFAPESP: 2017/01882-8
dc.description.sponsorshipIDFAPESP: 2016/24956-4
dc.description.sponsorshipIDCNPq: 446888/2014-1
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fendo.2018.00122
dc.identifier.citationFrontiers In Endocrinology. Lausanne, v. 9, 2018.
dc.identifier.doi10.3389/fendo.2018.00122
dc.identifier.fileWOS000428391400001.pdf
dc.identifier.issn1664-2392
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55801
dc.identifier.wosWOS:000428391400001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Endocrinology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmelatoninen
dc.subjectfeeding behavioren
dc.subjectpinealectomyen
dc.subjectleptin resistanceen
dc.subjectsignal-transducer and activator of transcription 3en
dc.subjectbrown adipose tissueen
dc.subjectthermogenesisen
dc.subjectoverweighten
dc.titleMelatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Ratsen
dc.typeinfo:eu-repo/semantics/article
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