Multidisciplinary Approach to the Treatment of Obese Adolescents: Effects on Cardiovascular Risk Factors, Inflammatory Profile, and Neuroendocrine Regulation of Energy Balance

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dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorCampos, Raquel Munhoz da Silveira [UNIFESP]
dc.contributor.authorCorgosinho, Flavia Campos [UNIFESP]
dc.contributor.authorSiegfried, Wolfgang
dc.contributor.authorCaranti, Danielle Arisa [UNIFESP]
dc.contributor.authorMasquio, Deborah Cristina Landi [UNIFESP]
dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorSanches, Priscila de Lima [UNIFESP]
dc.contributor.authorSilva, Patricia Leao da [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorDantas, Alexandre Dâmaso Aguilera
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorTock, Lian
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionObes Rehabil Ctr INSULA
dc.contributor.institutionWeight Sci
dc.date.accessioned2016-01-24T14:30:53Z
dc.date.available2016-01-24T14:30:53Z
dc.date.issued2013-01-01
dc.description.abstractThe prevention of obesity and health concerns related to body fat is a major challenge worldwide. the aim of this study was to investigate the role of a medically supervised, multidisciplinary approach, on reduction in the prevalence of obesity related comorbidities, inflammatory profile, and neuroendocrine regulation of energy balance in a sample of obese adolescents. A total of 97 postpuberty obese adolescents were enrolled in this study. Body composition, neuropeptides, and adipokines were analysed. the metabolic syndrome was defined by the International Diabetes Federation (IDF). the abdominal ultrasonography was performed to measure visceral, subcutaneous fat and hepatic steatosis. All measures were performed at baseline and after one year of therapy. the multidisciplinary management promoted the control of obesity reducing body fat mass. the prevalence of metabolic syndrome, asthma, nonalcoholic fatty liver disease (NAFLD), binge eating, and hyperleptinemia was reduced. An improvement in the inflammatory profile was demonstrated by an increase in anti-inflammatory adiponectin and reduction in proinflammatory adipokines, plasminogen activator inhibitor-1, interleukin-6 concentrations, and in the Lep/Adipo ratio. Moreover, a reduction in the AgRP and an increase in the alfa-MSH were noted. the multidisciplinary approach not only reduced obesity but also is efficacious in cardiovascular risk factors, inflammatory profile, and neuroendocrine regulation of energy balance.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Biosci, BR-11015020 Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Escola Paulista Med, Postgrad Program Nutr, BR-04020060 São Paulo, Brazil
dc.description.affiliationObes Rehabil Ctr INSULA, Insulaweg, Bischofswiesen, Germany
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Physiol, BR-04021001 São Paulo, Brazil
dc.description.affiliationWeight Sci, BR-05406000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, BR-04021001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Biosci, BR-11015020 Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Escola Paulista Med, Postgrad Program Nutr, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Physiol, BR-04021001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, BR-04021001 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCEPE
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipAFIP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFADA
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipUniversidade Federal de São Paulo
dc.description.sponsorshipIDFAPESP: 2006/00684-3
dc.description.sponsorshipIDFAPESP: 2008/53069-0
dc.description.sponsorshipIDFAPESP: 2011/503560
dc.description.sponsorshipIDFAPESP: 2011/50414-0
dc.description.sponsorshipIDFAPESP: 9814303-3
dc.description.sponsorshipIDCAPES: 2566/2011
dc.format.extent10
dc.identifierhttps://dx.doi.org/10.1155/2013/541032
dc.identifier.citationInternational Journal of Endocrinology. New York: Hindawi Publishing Corporation, 10 p., 2013.
dc.identifier.doi10.1155/2013/541032
dc.identifier.fileWOS000326751600001.pdf
dc.identifier.issn1687-8337
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/35696
dc.identifier.wosWOS:000326751600001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofInternational Journal of Endocrinology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMultidisciplinary Approach to the Treatment of Obese Adolescents: Effects on Cardiovascular Risk Factors, Inflammatory Profile, and Neuroendocrine Regulation of Energy Balanceen
dc.typeinfo:eu-repo/semantics/article
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