Effect of treatment with cholecalciferol on the membrane potential and contractility of aortae from spontaneously hypertensive rats

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dc.contributor.authorSilva, Eneida de Gusmao [UNIFESP]
dc.contributor.authorFredianineto, E.
dc.contributor.authorFerreira, A. T.
dc.contributor.authorPaiva, Antonio Cechelli de Mattos[UNIFESP]
dc.contributor.authorPaiva, Therezinha Bandiera [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T16:24:08Z
dc.date.available2018-06-15T16:24:08Z
dc.date.issued1996-07-01
dc.description.abstract1 The diet of spontaneously hypertensive rats (SHR) and normotensive Wistar rats (NWR) was supplemented with 12.5 mu g cholecalciferol per 100 g body weight daily, by gavage, for 4 weeks.2 The amplitude of the contractile responses of aortic rings from SHR to potassium and adrenaline, which was smaller than in NWR aortae, was increased after treatment with cholecalciferol. No further changes were observed in the responses of NWR and SHR aortae in the presence of 100 nM apamin.3 The membrane potentials of aortae from SHR, which were higher than those of aortae from NWR, decreased after treatment with cholecalciferol. Further depolarization was observed in aortic rings from NWR, but not in aortic rings from SHR, after their preincubation with 100 nM apamin.4 It is concluded that cholecalciferol normalizes the membrane potential and contractility of aortae from SHR, probably through an effect on lipid composition and structure of the plasma membrane.en
dc.description.affiliationESCOLA PAULISTA MED,DEPT BIOPHYS,BR-04023062 SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT BIOPHYS,BR-04023062 SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent1367-1370
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.1996.tb15546.x/full
dc.identifier.citationBritish Journal Of Pharmacology. Basingstoke: Stockton Press, v. 118, n. 6, p. 1367-1370, 1996.
dc.identifier.issn0007-1188
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43180
dc.identifier.wosWOS:A1996UY15700006
dc.language.isoeng
dc.publisherStockton Press
dc.relation.ispartofBritish Journal Of Pharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcholecalciferolen
dc.subjectspontaneously hypertensive ratsen
dc.subjectaortaen
dc.subjectmembrane potentialen
dc.subjectcontractionen
dc.titleEffect of treatment with cholecalciferol on the membrane potential and contractility of aortae from spontaneously hypertensive ratsen
dc.typeinfo:eu-repo/semantics/article
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