Dietary Medium-Chain Triacylglycerols versus Long-Chain Triacylglycerols for Body Composition in Adults: Systematic Review and Meta-analysis of Randomized Controlled Trials

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dc.contributor.authorBueno, Nassib B. [UNIFESP]
dc.contributor.authorMelo, Ingrid V. de
dc.contributor.authorFlorencio, Telma T.
dc.contributor.authorSawaya, Ana Lydia [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Alagoas
dc.date.accessioned2016-01-24T14:40:14Z
dc.date.available2016-01-24T14:40:14Z
dc.date.issued2015-03-04
dc.description.abstractObjective: To assess the effect of replacing dietary long-chain triacylglycerols (LCTs) with medium-chain triacylglycerols (MCTs) on body composition in adults.Methods: We conducted a meta-analysis of randomized controlled trials (RCTs), to determine whether individuals assigned to replace at least 5g of dietary LCTs with MCTs for a minimum of 4 weeks show positive modifications on body composition. We systematically searched, through July 2013, the CENTRAL, EMBASE, LILACS, and MEDLINE databases for RCTs that investigated the effects of MCT intake on body composition in adults. Two authors independently extracted data and assessed risk of bias. Weighted mean differences (WMDs) were calculated for net changes in the outcomes. We assessed heterogeneity by the Cochran Q test and I-2 statistic and publication bias with the Egger's test. Prespecified sensitivity analyses were performed.Results: in total, 11 trials were included, from which 5 presented low risk of bias. in the overall analysis, including all studies, individuals who replaced dietary LCT with MCT showed significantly reduced body weight (WMD, -0.69kg; 95% confidence interval [CI], -1.1 to -0.28; p = 0.001); body fat (-0.89kg; 95% CI, -1.27 to -0.51; p < 0.001), and WC (-1.78cm; 95% CI, -2.4 to -1.1; p < 0.001). the overall quality of the evidence was low to moderate. Trials with a crossover design were responsible for the heterogeneity.Conclusion: Despite statistically significant results, the recommendation to replace dietary LCTs with MCTs must be cautiously taken, because the available evidence is not of the highest quality.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Fisiol, Lab Fisiol Nutr, BR-04023060 São Paulo, SP, Brazil
dc.description.affiliationUniv Fed Alagoas, Inst Quim & Biotecnol, Lab Pesquisa Recursos Nat, Maceio, Brazil
dc.description.affiliationUniv Fed Alagoas, Ctr Recuperacao & Educ Nutr, Fac Nutr, Maceio, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Fisiol, Lab Fisiol Nutr, BR-04023060 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent175-183
dc.identifierhttp://dx.doi.org/10.1080/07315724.2013.879844
dc.identifier.citationJournal of the American College of Nutrition. Abingdon: Routledge Journals, Taylor & Francis Ltd, v. 34, n. 2, p. 175-183, 2015.
dc.identifier.doi10.1080/07315724.2013.879844
dc.identifier.issn0731-5724
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38878
dc.identifier.wosWOS:000353112300012
dc.language.isoeng
dc.publisherRoutledge Journals, Taylor & Francis Ltd
dc.relation.ispartofJournal of the American College of Nutrition
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.subjectwaist circumferenceen
dc.subjectweight lossen
dc.subjectmedium-chain triglyceridesen
dc.titleDietary Medium-Chain Triacylglycerols versus Long-Chain Triacylglycerols for Body Composition in Adults: Systematic Review and Meta-analysis of Randomized Controlled Trialsen
dc.typeinfo:eu-repo/semantics/article
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