EFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICE

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dc.citation.issue6
dc.citation.volume23
dc.contributor.authorBrianezi, Ledimar
dc.contributor.authorMarques, Mara Rubia
dc.contributor.authorCardoso, Clever Gomes
dc.contributor.authorde Jesus Miranda, Maria Luiza
dc.contributor.authorAffonso Fonseca, Fernando Luiz [UNIFESP]
dc.contributor.authorMesiano Maifrino, Laura Beatriz
dc.coverageSao Paulo Sp
dc.date.accessioned2020-09-01T13:21:20Z
dc.date.available2020-09-01T13:21:20Z
dc.date.issued2017
dc.description.abstractIntroduction: The emergence of coronary heart disease increases with menopause, physical inactivity and with dyslipidemia. It is known that physical training promotes the improvement of cardiovascular functions. Objective: The purpose of this study was to investigate the effects of aerobic physical training on the left ventricle in female LDL knockout ovariectomized mice. Methods: Thirty animals were divided into 6 groups (n=5), namely, sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized; sedentary ovariectomized; and trained ovariectomized. We analyzed the mean nuclear volume parameters, the cross sectional area of the myocytes, the apparent density of the capillaries, interstitium, myocytes and collagen fibers. Results: The results show that for the density of the number of nuclei, the physical activity decreased to values close to the ovariectomized control group. Regarding the mean nuclear volume and the average area of myocytes, training and ovariectomy promoted the elevation of these values but hypercholesterolemia was lower. the volume density of myocytes, hypercholesterolemia showed an increase of these values as well as the training. There was no change in the volumetric density of the capillaries and the density of collagen fibers. The training caused the decrease in the density of the interstitial volume, and the hypercholesterolemia changed to a smaller one than the control group. Conclusion: We concluded that the moderate aerobic activity or the training time used in our study were not sufficient to generate significant alterations in the hypercholesterolemic group.en
dc.description.affiliationUniv Sao Judas Tadeu, Programa Posgrad, Sao Paulo, SP, Brazil
dc.description.affiliationFac Adventista Hortolandia UNASP, Campus Hortolandia, Hortolandia, SP, Brazil
dc.description.affiliationUniv Fed Goias, Dept Histol Embriol & Biol Mol, Goiania, Go, Brazil
dc.description.affiliationFMABC, Lab Anal Clin, Santo Andre, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Ciencias Biol, Diadema, SP, Brazil
dc.description.affiliationInst Dante Pazzanese Cardiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Dept Ciencias Biol, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent441-445
dc.identifierhttp://dx.doi.org/10.1590/1517-869220172306160084
dc.identifier.citationRevista Brasileira De Medicina Do Esporte. Sao Paulo Sp, v. 23, n. 6, p. 441-445, 2017.
dc.identifier.doi10.1590/1517-869220172306160084
dc.identifier.fileS1517-86922017000600441.pdf
dc.identifier.issn1517-8692
dc.identifier.scieloS1517-86922017000600441
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58208
dc.identifier.wosWOS:000418605800003
dc.language.isoeng
dc.publisherSoc Brasileira Med Esporte
dc.relation.ispartofRevista Brasileira De Medicina Do Esporte
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectheart ventriclesen
dc.subjectexerciseen
dc.subjectmenopauseen
dc.titleEFFECTS OF PHYSICAL TRAINING ON THE MYOCARDIUM OF FEMALE LDL KNOCKOUT OVARIECTOMIZED MICEen
dc.typeinfo:eu-repo/semantics/article
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