Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions

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dc.contributor.authorMachado-Filho, Joao Ananias
dc.contributor.authorCorreia, Alyne Oliveira
dc.contributor.authorAires Montenegro, Anyssa Brilhante
dc.contributor.authorPereira Nobre, Maria Elizabeth
dc.contributor.authorCerqueira, Gilberto Santos
dc.contributor.authorTavares Neves, Kelly Rose
dc.contributor.authorNaffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.authorCastro Brito, Gerly Anne de
dc.contributor.authorBarros Viana, Glauce Socorro de
dc.contributor.institutionFac Med Estacio Juazeiro do Norte
dc.contributor.institutionUniv Fed Ceara
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:14Z
dc.date.available2016-01-24T14:37:14Z
dc.date.issued2014-05-01
dc.description.abstractSeveral lines of evidences have shown the inversion association between coffee consumption and Parkinson's disease (PD) development. Caffeine is a methylxanthine known as a non-selective inhibitor of A2A and A1 adenosine receptors in the brain and shown to be a neuroprotective drug. the objectives were to study caffeine effects in a unilateral 6-OHDA model of PD in rats. Male rats were divided into the following groups: sham-operated (SO), striatal 6-OHDA-lesioned and 6-OHDA-lesioned and treated for 2 weeks with caffeine (10 and 20 mg/kg, p.o.). Then, animals were subjected to behavioral (open field and apomorphine-induced rotations), neurochemical (striatal determinations of DA and DOPAC), histological (cresyl violet staining) and immunohistochemical (TH, TNF-alpha, IL-1 beta and HDAC) evaluations. the results showed that while the 6-OHDA group presented a decreased locomotor activity and a high number of apomorphine-induced rotations, these behaviors were partially blocked by caffeine. Caffeine itself increased DA contents and reversed the decrease in striatal DA observed in the 6-OHDA-lesioned group. Furthermore, it improved the hippocampal neuronal viability and significantly increased TH immunoreactivity in the striatum of the 6-OHDA-lesioned group. in addition, caffeine treatment also decreased the number of immunopositive cells for HDAC and pro-inflammatory cytokines TNF-alpha and IL-1 beta. All these effects points out to a neuroprotective effect of caffeine and its potential benefit in the prevention and treatment of PD. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationFac Med Estacio Juazeiro do Norte, Juazeiro Do Norte, CE, Brazil
dc.description.affiliationUniv Fed Ceara, Fac Med, Fortaleza, Ceara, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Expt Neurol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Expt Neurol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent116-125
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2014.01.051
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 264, p. 116-125, 2014.
dc.identifier.doi10.1016/j.bbr.2014.01.051
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37726
dc.identifier.wosWOS:000333853300013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCaffeineen
dc.subjectNeuroprotectionen
dc.subjectParkinson's diseaseen
dc.subjectPro-inflammatory cytokineen
dc.subject6-OHDA modelen
dc.subjectBehavioren
dc.titleCaffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitionsen
dc.typeArtigo
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