Prevalence and characteristics of adverse drug events in Brazil

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dc.citation.issue4
dc.citation.volume34
dc.contributor.authorOliveira de Sousa, Livia Alves
dc.contributor.authorde Franca Fonteles, Marta Maria
dc.contributor.authorMonteiro, Mirian Parente
dc.contributor.authorMengue, Sotero Serrate
dc.contributor.authorBertoldi, Andrea Damaso
dc.contributor.authorDal Pizzol, Tatiane da Silva
dc.contributor.authorLeao Tavares, Noemia Urruth
dc.contributor.authorOliveira, Maria Auxiliadora
dc.contributor.authorLuiza, Vera Lucia
dc.contributor.authorRamos, Luiz Roberto [UNIFESP]
dc.contributor.authorFarias, Mareni Rocha
dc.contributor.authorDourado Arrais, Paulo Sergio
dc.coverageRio De Janiero
dc.date.accessioned2020-07-02T18:51:54Z
dc.date.available2020-07-02T18:51:54Z
dc.date.issued2018
dc.description.abstractThe aim of this study was to describe the prevalence of adverse drug events (ADEs) and associated factors reported by users of medicines in Brazil. This was a cross-sectional population-based study conducted from September 2013 to February 2014 with data from the Brazilian National Survey on Access, Use, and Promotion of Rational Use of Medicines (PNAUM). The study included all individuals that reported the use of medicines and identified, among them, all those reporting at least one problem with the medicine's use. A descriptive analysis was performed to estimate ADE prevalence and 95% confidence intervals (95% CI) among the target variables. Crude and adjusted prevalence ratios were calculated using Poisson regression to investigate factors associated with ADEs. Overall ADE prevalence in Brazil was 6.6% (95% CI: 5.89-7.41), and after multivariate analysis, higher prevalence was associated with female gender, residence in the Central and Northeast regions, consumption of more medicines, "bad" self-rated health, and self-medication. The drugs most frequently reported with ADEs were fluoxetine, diclofenac, and amitriptyline. The most frequent ADEs were somnolence, epigastric pain, and nausea. Most reported ADEs were mild, avoidable, and associated with medicines used frequently by the population. The study provided knowledge on the size of the problem with use of medicines in Brazil.en
dc.description.affiliationUniv Fed Ceara, Fac Farm Odontol & Enfermagem, Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Dept Med Social, Porto Alegre, RS, Brazil
dc.description.affiliation[Bertoldi, Andrea Damaso] Univ Fed Pelotas, Dept Med Social, Pelotas, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Fac Farm, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Brasilia, Fac Ciencias Saude, Brasilia, DF, Brazil
dc.description.affiliationFundacao Oswaldo Cruz, Escola Nacl Saude Publ Sergio Arouca, Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Santa Catarina, Ctr Ciencias Saude, Florianopolis, SC, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipDepartments of Science and Technology (Decit) of the Secretariat of Science, Technology, and Strategic Inputs of the Brazilian Ministry of Health
dc.description.sponsorshipPharmaceutical Care (DAF) of the Secretariat of Science, Technology, and Strategic Inputs of the Brazilian Ministry of Health
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1590/0102-311X00040017
dc.identifier.citationCadernos De Saude Publica. Rio De Janiero, v. 34, n. 4, p. -, 2018.
dc.identifier.doi10.1590/0102-311X00040017
dc.identifier.fileWOS000429219100001.pdf
dc.identifier.issn0102-311X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53762
dc.identifier.wosWOS:000429219100001
dc.language.isoeng
dc.publisherCadernos Saude Publica
dc.relation.ispartofCadernos De Saude Publica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDrug Utilizationen
dc.subjectDrug-Related Side Effects and Adverse Reactionsen
dc.subjectPharmacovigilanceen
dc.subjectHealth Surveysen
dc.titlePrevalence and characteristics of adverse drug events in Brazilen
dc.typeinfo:eu-repo/semantics/article
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