Revealing the role of the autonomic nervous system in the development and maintenance of Goldblatt hypertension in rats

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dc.contributor.authorOliveira-Sales, Elizabeth Barbosa de [UNIFESP]
dc.contributor.authorToward, Marie Ann
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.authorJulian Francis Richmond
dc.contributor.institutionUniv Bristol
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:28Z
dc.date.available2016-01-24T14:37:28Z
dc.date.issued2014-07-01
dc.description.abstractDespite extensive use of the renovascular/Goldblatt model of hypertension-2K-1C, and the use of renal denervation to treat drug resistant hypertensive patients, autonomic mechanisms that underpin the maintenance of this hypertension are important yet remain unclear. Our aim was to analyse cardiovascular autonomic function by power spectral density analysis of both arterial pressure and pulse interval measured continuously by radio telemetry for 6 weeks after renal artery clipping. Mean arterial pressure increased from 106 +/- 5 to 185 +/- 2 mm Hg during 5 weeks post clipping when it stabilized. A tachycardia developed during the 4th week, which plateaued between weeks 5 and 6. the gain of the cardiac vagal baroreflex decreased immediately after clipping and continued to do so until the 5th week when it plateaued (from -2.4 +/- 0.09 to -0.8 +/- 0.04 bpm/mm Hg; P < 0.05). A similar time course of changes in the high frequency power spectral density of the pulse interval was observed (decrease from 13.4 +/- 0.6 to 8.3 +/- 0.01 ms(2); P < 0.05). There was an increase in both the very low frequency and low frequency components of systolic blood pressure that occurred 3 and 4 weeks after clipping, respectively. Thus, we show for the first time the temporal profile of autonomic mechanisms underpinning the initiation, development and maintenance of renovascular hypertension including: an immediate depression of cardiac baroreflex gain followed by a delayed cardiac sympathetic predominance; elevated sympathetic vasomotor drive occurring after the initiation of the hypertension but coinciding during its mid-development and maintenance. (C) 2014 the Authors. Published by Elsevier B.V.en
dc.description.affiliationUniv Bristol, Sch Physiol & Pharmacol, Bristol BS8 1TD, Avon, England
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Physiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Physiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipBritish Heart Foundation
dc.description.sponsorshipNIH
dc.format.extent23-29
dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2014.02.001
dc.identifier.citationAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 183, p. 23-29, 2014.
dc.identifier.doi10.1016/j.autneu.2014.02.001
dc.identifier.fileWOS000339137800005.pdf
dc.identifier.issn1566-0702
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37883
dc.identifier.wosWOS:000339137800005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAutonomic Neuroscience-basic & Clinical
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAutonomic nervous systemen
dc.subjectSpectral analysisen
dc.subject2K-1C hypertensionen
dc.titleRevealing the role of the autonomic nervous system in the development and maintenance of Goldblatt hypertension in ratsen
dc.typeinfo:eu-repo/semantics/article
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