Nutrition and chronic renal failure in rats: What if is an optimal dietary protein?

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dc.contributor.authorMeireles, Christiane Lumachi [UNIFESP]
dc.contributor.authorPrice, S Russ
dc.contributor.authorPereira, Aline Maria Luiz [UNIFESP]
dc.contributor.authorCarvalhaes, João Tomás de Abreu [UNIFESP]
dc.contributor.authorMitch, William E.
dc.contributor.institutionBrigham & Womens Hosp
dc.contributor.institutionHarvard Univ
dc.contributor.institutionTufts Univ
dc.contributor.institutionAustin & Repatriat Med Ctr
dc.contributor.institutionInst Univ CEMIC
dc.contributor.institutionUniv Kansas
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T10:46:27Z
dc.date.available2018-06-18T10:46:27Z
dc.date.issued1999-11-01
dc.description.abstractIn chronic uremia (CRF), malnutrition is an important determinant of morbidity in adults and impaired growth in children. Causes of malnutrition include anorexia and abnormal protein and amino acid metabolism. To determine how different levels of dietary protein and CRF interact to influence growth and nutritional status, CRF and sham-operated, pair-fed control rats were fed isocaloric diets containing 8, 17, or 30% protein for 21 d to mimic dietary regimens recommended for CRF patients: the minimum daily requirement; the recommended daily allowance; or an excess of dietary protein. Serum creatinine did not differ between groups of CRF rats but blood urea nitrogen was lowest in CRF rats fed 8% protein (P < 0.001). CRF rats eating 30% protein gained less weight and length compared to their controls or CRF rats fed 8 or 17% protein (P < 0.05); they also had acidemia. CRF rats fed 8% protein had the highest efficiency of utilization of protein for growth, while 17% protein promoted the highest efficiency of utilization of food and calories for growth. Notably, CRF rats eating 30% protein had the lowest protein efficiency; their calorie intake was also the lowest because of anorexia. Plasma branched-chain amino acids were progressively higher in control rats eating 8, 17, or 30% protein. CRF rats fed 8 or 17% protein had lower branched-chain amino acid concentrations compared with CRF rats fed 30% protein. In CRF, it is concluded that excessive dietary protein impairs growth but a law-protein diet does not impair nutritional responses and permits utilization of protein for growth if calories are sufficient.en
dc.description.affiliationEmory Univ, Sch Med, Div Renal, Atlanta, GA 30322 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Clin Nephrol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Clin Nephrol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1674-1680
dc.identifierhttp://jasn.asnjournals.org/content/10/11/2367.abstract
dc.identifier.citationJournal Of The American Society Of Nephrology. Philadelphia: Lippincott Williams & Wilkins, v. 10, n. 11, p. 2367-2373, 1999.
dc.identifier.issn1046-6673
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44751
dc.identifier.wosWOS:000083328100013
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal Of The American Society Of Nephrology
dc.rightsAcesso restrito
dc.titleNutrition and chronic renal failure in rats: What if is an optimal dietary protein?en
dc.typeArtigo
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