Five-year follow-up of patients with epidemic glomerulonephritis due to Streptococcus zooepidemicus
| dc.contributor.author | Sesso, Ricardo [UNIFESP] | |
| dc.contributor.author | Pinto, SWL | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.contributor.institution | Hosp Sao Joao Deus | |
| dc.date.accessioned | 2016-01-24T12:38:01Z | |
| dc.date.available | 2016-01-24T12:38:01Z | |
| dc.date.issued | 2005-09-01 | |
| dc.description.abstract | Background. in 1998 there was a large outbreak of acute glomerulonephritis in Nova Serrana, Brazil, caused by group C Streptococcus zooepidemicus. This study describes the follow-up of these patients, after a mean time of 5.4 years of the acute episode.Methods. of 135 cases identified in 1998, 56 were re-examined in a prospective study and had measurements of blood pressure, creatinine clearance (estimated by the Cockcroft and Gault formula), microalbuminuria (radioimmunoassay), urine sediment analysis and a protein dipstick test.Results. of the original group of 135 subjects, 3 died in the acute phase and 5 (3.7 %) required chronic dialysis. of the 56 cases re-evaluated, 54 (96 %) were adults (mean +/- SD age, 43 +/- 17 years) and 36 (64 %) females. At the follow-up examination, we found arterial hypertension in 30 % (n = 17/56) of the subjects, reduced creatinine clearance (<80ml/min) in 49 % (n = 26/53) and increased microalbuminuria (> 20 mu g/min) in 22 % (n=11/51). Compared to the evaluation carried out 3 years before, the number of cases with creatinine clearance lower than 80ml/min increased from 20 to 26 (of 53 cases). Increased microalbuminuria and/or reduced creatinine clearance were detected in 57 % (n = 32/56) of the subjects. Patients with reduced creatinine clearance were older than those without reduced renal function (54 +/- 15 vs 34 +/- 12 years, P < 0.001).Conclusions. After a mean time of 5.4 years, a relatively high proportion of patients with epidemic poststreptococcal glomerulonephritis due to S.zooepidemicus present hypertension, reduced renal function and increased microalbuminuria. | en |
| dc.description.affiliation | Unifesp, Esola Paulista Med, Div Nephrol, BR-04023900 São Paulo, SP, Brazil | |
| dc.description.affiliation | Hosp Sao Joao Deus, Div Nephrol, Sao Joao Deus, Brazil | |
| dc.description.affiliationUnifesp | Unifesp, Esola Paulista Med, Div Nephrol, BR-04023900 São Paulo, SP, Brazil | |
| dc.description.source | Web of Science | |
| dc.format.extent | 1808-1812 | |
| dc.identifier | http://dx.doi.org/10.1093/ndt/gfh904 | |
| dc.identifier.citation | Nephrology Dialysis Transplantation. Oxford: Oxford Univ Press, v. 20, n. 9, p. 1808-1812, 2005. | |
| dc.identifier.doi | 10.1093/ndt/gfh904 | |
| dc.identifier.issn | 0931-0509 | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/28432 | |
| dc.identifier.wos | WOS:000231517900007 | |
| dc.language.iso | eng | |
| dc.publisher | Oxford Univ Press | |
| dc.relation.ispartof | Nephrology Dialysis Transplantation | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.license | http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html | |
| dc.subject | acute nephritis | en |
| dc.subject | epidemic nephritis | en |
| dc.subject | follow-up | en |
| dc.subject | poststreptococcal glomerulonephritis | en |
| dc.subject | Streptococcus zooepidemicus | en |
| dc.title | Five-year follow-up of patients with epidemic glomerulonephritis due to Streptococcus zooepidemicus | en |
| dc.type | info:eu-repo/semantics/article |