The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella Pneumoniae Infection in the Lung

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dc.citation.volume9
dc.contributor.authorGalvao, Izabela
dc.contributor.authorTavares, Luciana P.
dc.contributor.authorCorrea, Renan O.
dc.contributor.authorFachi, Jose Luis
dc.contributor.authorRocha, Vitor Melo
dc.contributor.authorRungue, Marcela
dc.contributor.authorGarcia, Cristiana C.
dc.contributor.authorCassali, Geovanni
dc.contributor.authorFerreira, Caroline M. [UNIFESP]
dc.contributor.authorMartins, Flaviano S.
dc.contributor.authorOliveira, Sergio C.
dc.contributor.authorMackay, Charles R.
dc.contributor.authorTeixeira, Mauro M.
dc.contributor.authorVinolo, Marco Aurelio R.
dc.contributor.authorVieira, Angelica T.
dc.coverageLausanne
dc.date.accessioned2020-07-08T13:09:40Z
dc.date.available2020-07-08T13:09:40Z
dc.date.issued2018
dc.description.abstractPneumonia is one of the leading causes of death and mortality worldwide. The inflammatory responses that follow respiratory infections are protective leading to pathogen clearance but can also be deleterious if unregulated. The microbiota is known to be an important protective barrier against infections, mediating both direct inhibitory effects against the potential pathogen and also regulating the immune responses contributing to a proper clearance of the pathogen and return to homeostasis. GPR43 is one receptor for acetate, a microbiota metabolite shown to induce and to regulate important immune functions. Here, we addressed the role of GPR43 signaling during pulmonary bacterial infections. We have shown for the first time that the absence of GPR43 leads to increased susceptibility to Klebsiella pneumoniae infection, which was associated to both uncontrolled proliferation of bacteria and to increased inflammatory response. Mechanistically, we showed that GPR43 expression especially in neutrophils and alveolar macrophages is important for bacterial phagocytosis and killing. In addition, treatment with the GPR43 ligand, acetate, is protective during bacterial lung infection. This was associated to reduction in the number of bacteria in the airways and to the control of the inflammatory responses. Altogether, GPR43 plays an important role in the "gut-lung axis" as a sensor of the host gut microbiota activity through acetate binding promoting a proper immune response in the lungs.en
dc.description.affiliationUniv Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Genet Evolut & Bioagents, Campinas, SP, Brazil
dc.description.affiliationFiocruz MS, Inst Oswaldo Cruz, Lab Resp Viruses & Measles, Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Inst Biol Sci, Dept Gen Pathol, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Diadema, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Inst Biol Sci, Dept Microbiol, Belo Horizonte, MG, Brazil
dc.description.affiliationMonash Univ, Dept Immunol, Melborne, Vic, Australia
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Diadema, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacnao de aperfeicoamento de pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipRede Mineira de Imunobiologicos from the Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipAustralian National Health and Medical Research Council (NHMRC)
dc.description.sponsorshipPro-reitoria de Pesquisa, Universidade Federal de Minas Gerais (PRPQ-UFMG)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipFundacao de Desenvolvimento da Unicamp (Funcamp)
dc.description.sponsorshipIDFAPEMIG: RED-00140-16
dc.description.sponsorshipIDPRPQ-UFMG: 23853
dc.description.sponsorshipIDFAPESP:12/10653-9, 14/22909-3
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3389/fimmu.2018.00142
dc.identifier.citationFrontiers In Immunology. Lausanne, v. 9, p. -, 2018.
dc.identifier.doi10.3389/fimmu.2018.00142
dc.identifier.fileWOS000425521100001.pdf
dc.identifier.issn1664-3224
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54123
dc.identifier.wosWOS:000425521100001
dc.language.isoeng
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectlung infectionen
dc.subjectGPR43en
dc.subjectinflammationen
dc.subjectmicrobiotaen
dc.subjectshort-chain fatty acidsen
dc.subjectpneumoniaen
dc.titleThe Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella Pneumoniae Infection in the Lungen
dc.typeinfo:eu-repo/semantics/article
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