Blood pressure reducing effects of Phalaris canariensis in normotensive and spontaneously hypertensive rats

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dc.contributor.authorPassos, Clevia Santos [UNIFESP]
dc.contributor.authorCarvalho, Lucimeire Nova [UNIFESP]
dc.contributor.authorPontes, Roberto Braz [UNIFESP]
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.authorIkuta, Olinda [UNIFESP]
dc.contributor.authorBoim, Mirian Aparecida [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:50Z
dc.date.available2016-01-24T14:17:50Z
dc.date.issued2012-02-01
dc.description.abstractThe birdseed Phalaris canariensis (Pc) is popularly used as an antihypertensive agent. the aqueous extract of Pc (AEPc) was administered in adult normotensive Wistar rats and spontaneously hypertensive rats (SHR) and in prehypertensive young SHR (SHRY, 3 weeks old). Animals received AEPc (400 mg.kg(-1).day(-1), by gavage) for 30 days, then groups were divided into 2 subgroups: one was treated for another 30 days and the other received water instead of AEPc for 30 days. AEPc reduced systolic blood pressure (SBP) in both adult groups; however, treatment interruption was followed by a gradual return of the SBP to baseline levels. SHRY became hypertensive 30 days after weaning. AEPc minimized the increase in SBP in SHRY, but blood pressure rose to levels similar to those in the untreated group with treatment interruption. There were no changes in renal function, diuresis, or Na+ excretion. Pc is rich in tryptophan, and the inhibition of the metabolism of tryptophan to kynurenine, a potential vasodilator factor, prevented the blood pressure reducing effect of AEPc. Moreover, AEPc significantly reduced sympathoexcitation. Data indicate that the metabolic derivative of tryptophan, kinurenine, may be a mediator of the volume-independent antihypertensive effect of Pc, which was at least in part mediated by suppression of the sympathetic tonus.en
dc.description.affiliationFed Univ São Paulo UNIFESP, Div Renal, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, Cardiovasc Div, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Div Renal, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, Cardiovasc Div, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundacao Oswaldo Ramos (FOR)
dc.format.extent201-208
dc.identifierhttp://dx.doi.org/10.1139/Y11-120
dc.identifier.citationCanadian Journal of Physiology and Pharmacology. Ottawa: Canadian Science Publishing, Nrc Research Press, v. 90, n. 2, p. 201-208, 2012.
dc.identifier.doi10.1139/Y11-120
dc.identifier.issn0008-4212
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34552
dc.identifier.wosWOS:000300617800008
dc.language.isoeng
dc.publisherCanadian Science Publishing, Nrc Research Press
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthypertensionen
dc.subjectPhalaris canariensisen
dc.subjectrenal functionen
dc.subjecttryptophanen
dc.subjectkynurenineen
dc.subjectSHRen
dc.subjectsympathetic toneen
dc.titleBlood pressure reducing effects of Phalaris canariensis in normotensive and spontaneously hypertensive ratsen
dc.typeinfo:eu-repo/semantics/article
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