Incorporation of bioactive glass in calcium phosphate cement: Material characterization and in vitro degradation

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dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.contributor.authorNejadnik, M. R.
dc.contributor.authorvan de Watering, F. C. J.
dc.contributor.authorCrovace, Murilo Camuri
dc.contributor.authorZanotto, Edgar Dutra
dc.contributor.authorHoefnagels, J. P. M.
dc.contributor.authorWolke, J. G. C.
dc.contributor.authorJansen, J. A.
dc.contributor.authorvan den Beucken, Jeroen J. J. P.
dc.contributor.institutionRadboud Univ Nijmegen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionEindhoven Univ Technol TU E
dc.date.accessioned2016-01-24T14:32:02Z
dc.date.available2016-01-24T14:32:02Z
dc.date.issued2013-08-01
dc.description.abstractCalcium phosphate cements (CPCs) have been widely used as an alternative to biological grafts due to their excellent osteoconductive properties. Although degradation has been improved by using poly(D,L-lactic-co-glycolic) acid (PLGA) microspheres as porogens, the biological performance of CPC/PLGA composites is insufficient to stimulate bone healing in large bone defects. in this context, the aim of this study was to investigate the effect of incorporating osteopromotive bioactive glass (BG; up to 50 wt %) on setting properties, in vitro degradation behavior and morphological characteristics of CPC/BG and CPC/PLGA/BG. the results revealed that the initial and final setting time of the composites increased with increasing amounts of incorporated BG. the degradation test showed a BG-dependent increasing effect on pH of CPC/BG and CPC/PLGA/BG pre-set scaffolds immersed in PBS compared to CPC and CPC/PLGA equivalents. Whereas no effects on mass loss were observed for CPC and CPC/BG pre-set scaffolds, CPC/PLGA/BG pre-set scaffolds showed an accelerated mass loss compared with CPC/PLGA equivalents. Morphologically, no changes were observed for CPC and CPC/BG pre-set scaffolds. in contrast, CPC/PLGA and CPC/PLGA/BG showed apparent degradation of PLGA microspheres and faster loss of integrity for CPC/PLGA/BG pre-set scaffolds compared with CPC/PLGA equivalents. Based on the present in vitro results, it can be concluded that BG can be successfully introduced into CPC and CPC/PLGA without exceeding the setting time beyond clinically acceptable values. All injectable composites containing BG had suitable handling properties and specifically CPC/PLGA/BG showed an increased rate of mass loss. Future investigations should focus on translating these findings to in vivo applications. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.en
dc.description.affiliationRadboud Univ Nijmegen, Med Ctr, Dept Biomat 309, NL-6500 HB Nijmegen, Netherlands
dc.description.affiliationFed Univ São Paulo UNIFESP, Dept Biosci, BR-11050240 Santos, SP, Brazil
dc.description.affiliationFed Univ Sao Carlos UFSCar, Vitreous Mat Lab LaMaV, Dept Mat Engn, BR-16015223 Sao Carlos, SP, Brazil
dc.description.affiliationEindhoven Univ Technol TU E, Grp Mech Mat, Dept Mech Engn, NL-5612 AZ Eindhoven, Netherlands
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Dept Biosci, BR-11050240 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNetherlands Ministry of Economic Affairs
dc.description.sponsorshipNetherlands Ministry of Education, Culture and Science
dc.format.extent2365-2373
dc.identifierhttps://doi.org/10.1002/jbm.a.34531
dc.identifier.citationJournal of Biomedical Materials Research Part A. Hoboken: Wiley-Blackwell, v. 101, n. 8, p. 2365-2373, 2013.
dc.identifier.doi10.1002/jbm.a.34531
dc.identifier.issn1549-3296
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/36577
dc.identifier.wosWOS:000320778000024
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Biomedical Materials Research Part A
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectCalcium phosphate cementen
dc.subjectBioactive glassen
dc.subjectPoly (Den
dc.subjectL-lactic-co-glycolic) aciden
dc.subjectDegradationen
dc.subjectin vitroen
dc.titleIncorporation of bioactive glass in calcium phosphate cement: Material characterization and in vitro degradationen
dc.typeinfo:eu-repo/semantics/article
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