Osteopenia occurs in a minority of patients with acromegaly and is predominant in the spine
| dc.contributor.author | Kayath, M. J. | |
| dc.contributor.author | Vieira, JGH | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2016-01-24T12:30:15Z | |
| dc.date.available | 2016-01-24T12:30:15Z | |
| dc.date.issued | 1997-01-01 | |
| dc.description.abstract | Acromegaly may induce abnormalities in bone metabolism; however, there are limited data related to bone mineral density (BMT)) in this condition. To evaluate the effects of an excess of growth hormone/insulin-like growth fractor I(GH/IGF-I) in the skeleton, we measured the BMD in spine and femoral region, total body calcium and body composition in 45 patients (24 females and 21 males) aged 21-77 years (median 43 years) with acromegaly for 11.4 +/- 7.5 years (range 0.5-26 years) using a dual-energy X-ray absorptiometer (Lunar DPX). Thirty-four patients had had hypogonadism fur 8.6 +/- 6.5 years (1-24 years). Mean serum GH and IGF-I levels were respectively 159 +/- 183 mu g/l and 843 +/- 497 mu g/l. Total body calcium was increased in the acromegalics (males: 1272 +/- 217 g, range 916-1816 g; females: 1041 +/- 223 g,range 739-1609 g)when compared with normal individuals (males: 1115 +/- 144 g, range 856-1398 g; females: 909 +/- 144 g, range 511-1311 g; p = 0.01). the lean body mass was significantly higher in acromegalic patients (p<0.001) compared with normal individuals. There was a tendency for a lower fat percentage in the acromegalics; however, this difference was not significant. Osteopenia (I Z-score below the mean) was found in the spine in 20% (n = 9) of the patients, while BMD was decreased in the femoral region in only 8.8% (n = 4). the group with osteopenia had a greater duration of hypogonadism than the normal BMD group (14 +/- 11 years vs 4.4 +/- 4.0 years;p = 0.01). A negative correlation was also found between the duration of hypogonadism and BMT) in spine (r = -0.4; p = 0.003) and femoral region (r = -0.37; p = 0.013), the hypogonadal patients had a lower BMD in spine (p<0.005), but not in other regions analyzed. No correlation was found between duration of hypersomatotropism, GH/IGF-I levels and BMD. We conclude that the majority of patients with acromegaly have preserved BMD despite the presence of hypogonadism. | en |
| dc.description.affiliation | Universidade Federal de São Paulo,ESCOLA PAULISTA MED,DIV ENDOCRINOL,CAIXA POSTAL 20266,BR-04034970 São Paulo,BRAZIL | |
| dc.description.affiliationUnifesp | Universidade Federal de São Paulo,ESCOLA PAULISTA MED,DIV ENDOCRINOL,CAIXA POSTAL 20266,BR-04034970 São Paulo,BRAZIL | |
| dc.description.source | Web of Science | |
| dc.format.extent | 226-230 | |
| dc.identifier | http://dx.doi.org/10.1007/BF01622293 | |
| dc.identifier.citation | Osteoporosis International. Godalming: Springer-verlag London Ltd, v. 7, n. 3, p. 226-230, 1997. | |
| dc.identifier.doi | 10.1007/BF01622293 | |
| dc.identifier.issn | 0937-941X | |
| dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/25654 | |
| dc.identifier.wos | WOS:A1997XD93400009 | |
| dc.language.iso | eng | |
| dc.publisher | Springer | |
| dc.relation.ispartof | Osteoporosis International | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.license | http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 | |
| dc.subject | acromegaly | en |
| dc.subject | bone mineral density | en |
| dc.subject | hypogonadism | en |
| dc.subject | osteoporosis | en |
| dc.title | Osteopenia occurs in a minority of patients with acromegaly and is predominant in the spine | en |
| dc.type | info:eu-repo/semantics/article |