Tonin and kallikrein in the brain of transgenic rat line expressing human tissue kallikrein

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dc.contributor.authorLomez, ESL
dc.contributor.authorAraujo, R. C.
dc.contributor.authorBader, Michael [UNIFESP]
dc.contributor.authorPesquero, João Bosco [UNIFESP]
dc.contributor.authorPesquero, J. L.
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMax Delbruck Ctr Mol Med
dc.date.accessioned2016-01-24T12:33:14Z
dc.date.available2016-01-24T12:33:14Z
dc.date.issued2002-02-01
dc.description.abstractA transgenic rat line harboring the human tissue kallikrein gene was investigated for expression and activity of tonin and kallikrein in different regions of the brain. the introduction of the transgene into the rat genome produced a significant augmentation of the expression levels and activity of rat tissue kallikrein. the possibility that human kallikrein does not hydrolyze the rat substrate is probably responsible for the augmented expression of the rat enzyme. On the other hand, although expression of tonin was significantly reduced, tonin activity was not altered in most brain structures, except for cerebellum and neurohypophysis.en
dc.description.affiliationUniv Fed Minas Gerais, ICB, Dept Fisiol & Biofis, BR-31270901 Belo Horizonte, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationMax Delbruck Ctr Mol Med, Berlin, Germany
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent229-232
dc.identifierhttp://dx.doi.org/10.1161/hy0202.104264
dc.identifier.citationHypertension. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 2, p. 229-232, 2002.
dc.identifier.doi10.1161/hy0202.104264
dc.identifier.issn0194-911X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26741
dc.identifier.wosWOS:000174045700008
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofHypertension
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecttoninen
dc.subjectkallikreinen
dc.subjectangiotensin IIen
dc.subjectratsen
dc.subjectbrainen
dc.titleTonin and kallikrein in the brain of transgenic rat line expressing human tissue kallikreinen
dc.typeinfo:eu-repo/semantics/article
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