GM1 ganglioside induces vasodilation and increases catalase content in the brain

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dc.contributor.authorFurian, Ana Flavia
dc.contributor.authorOliveira, Mauro Schneider
dc.contributor.authorRoyes, Luiz Fernando Freire
dc.contributor.authorFiorenza, Natalia Gindri
dc.contributor.authorFighera, Michele Rechia
dc.contributor.authorMyskiw, Jociane Carvalho
dc.contributor.authorWeiblen, Rudi
dc.contributor.authorRubin, Maribel Antonello
dc.contributor.authorFrussa-Filho, Roberto
dc.contributor.authorMello, Carlos Fernando
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:05Z
dc.date.available2016-01-24T13:49:05Z
dc.date.issued2007-09-15
dc.description.abstractMonosialoganglioside (GM1) is a glycosphingolipid present in most cell membranes that displays antioxidant and neuroprotective properties. GM I increases catalase activity in cerebral cortices in vivo, but the mechanisms underlying this effect of GM I are not known. in the current study we investigated the effect of GM1 (50 mg/kg, ip) on the content of hemoglobin and catalase activity of hippocampus, cortex, and striatum of rats. GM I administration increased catalase activity and hemoglobin content in brain samples after 30 min, but had no effect on blood catalase activity. GM1-induced increase in catalase activity was abolished by brain perfusion with heparinized saline. Brain catalase activity in the absence of blood, estimated by regression analysis of data from perfused and nonperfused animals, was not altered by the systemic injection of GM1. Moreover, the addition of GM1 (30 or 100 mu M) did not increase catalase activity in slices of cerebral cortex in situ, further suggesting that blood circulation is required for this effect. the GM1-induced vasodilation was confirmed in vivo, because the systemic injection of GM1 (50 mg/kg, ip) increased (1.2-1.6 times) the width of pial vessels. (c) 2007 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Santa Maria, Dept Fis & Farmacol, BR-97105900 Santa Maria, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Program Posgrad Ciencias Biol Bioquim, BR-90035003 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Santa Maria, Dept Educ Fis & Desportos, BR-97105900 Santa Maria, RS, Brazil
dc.description.affiliationUniv Fed Santa Maria, Dept Pediat, BR-97105900 Santa Maria, RS, Brazil
dc.description.affiliationUniv Fed Santa Maria, Dept Microbiol & Parasitol, BR-97105900 Santa Maria, RS, Brazil
dc.description.affiliationUniv Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent924-932
dc.identifierhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.05.035
dc.identifier.citationFree Radical Biology and Medicine. New York: Elsevier B.V., v. 43, n. 6, p. 924-932, 2007.
dc.identifier.doi10.1016/j.freeradbiomed.2007.05.035
dc.identifier.issn0891-5849
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30045
dc.identifier.wosWOS:000249190500007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFree Radical Biology and Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectantioxidanten
dc.subjectGM1 gangliosideen
dc.subjectneurodegenerative diseasesen
dc.subjectneuroprotectionen
dc.subjectcatalaseen
dc.subjectvasodilationen
dc.subjecthippocampusen
dc.subjectcortexen
dc.subjectstriatumen
dc.subjectfree radicalsen
dc.titleGM1 ganglioside induces vasodilation and increases catalase content in the brainen
dc.typeinfo:eu-repo/semantics/article
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