Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis

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dc.contributor.authorBlaber, Michael
dc.contributor.authorYoon, Hyesook
dc.contributor.authorJuliano, Maria A. [UNIFESP]
dc.contributor.authorScarisbrick, Isobel A.
dc.contributor.authorBlaber, Sachiko I.
dc.contributor.institutionFlorida State Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMayo Clin & Mayo Grad Sch Med
dc.contributor.institutionMayo Grad Sch
dc.date.accessioned2016-01-24T13:59:34Z
dc.date.available2016-01-24T13:59:34Z
dc.date.issued2010-04-01
dc.description.abstractA large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. the emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.en
dc.description.affiliationFlorida State Univ, Dept Biomed Sci, Tallahassee, FL 32306 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biophys, Escola Paulista Med, BR-0404420 São Paulo, Brazil
dc.description.affiliationMayo Clin & Mayo Grad Sch Med, Program Mol Neurosci, Rochester, MN 55905 USA
dc.description.affiliationMayo Clin & Mayo Grad Sch Med, Dept Neurol, Rochester, MN 55905 USA
dc.description.affiliationMayo Clin & Mayo Grad Sch Med, Dept Phys Med & Rehabil, Rochester, MN 55905 USA
dc.description.affiliationMayo Grad Sch, Program Mol Neurosci, Rochester, MN 55905 USA
dc.description.affiliationMayo Grad Sch, Dept Neurol, Rochester, MN 55905 USA
dc.description.affiliationMayo Grad Sch, Dept Phys Med & Rehabil, Rochester, MN 55905 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biophys, Escola Paulista Med, BR-0404420 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent311-320
dc.identifierhttp://dx.doi.org/10.1515/BC.2010.024
dc.identifier.citationBiological Chemistry. Berlin: Walter de Gruyter & Co, v. 391, n. 4, p. 311-320, 2010.
dc.identifier.doi10.1515/BC.2010.024
dc.identifier.issn1431-6730
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32462
dc.identifier.wosWOS:000276338100003
dc.language.isoeng
dc.publisherWalter de Gruyter & Co
dc.relation.ispartofBiological Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectactivation cascadeen
dc.subjectkallikreinen
dc.subjectkallikrein-related peptidase (KLK)en
dc.subjectplasminen
dc.subjectthrombogenesisen
dc.subjectthrombolysisen
dc.subjectthrombostasisen
dc.titleFunctional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axisen
dc.typeinfo:eu-repo/semantics/article
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