Heart rate recovery improvement in patients following acute myocardial infarction: exercise training, -blocker therapy or both

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dc.citation.issue3
dc.citation.volumev. 38
dc.contributor.authorMedeiros, Wladimir Musetti [UNIFESP]
dc.contributor.authorLuca, Fabio A. de
dc.contributor.authorFigueredo Junior, Alcides R. de [UNIFESP]
dc.contributor.authorMendes, Felipe A. R.
dc.contributor.authorGun, Carlos
dc.coverageHoboken
dc.date.accessioned2020-07-20T16:30:55Z
dc.date.available2020-07-20T16:30:55Z
dc.date.issued2018
dc.description.abstractHeart rate recovery (HRR) is a strong mortality predictor. Exercise training (ET) and -blocker therapy have significant impact on the HRR of patients following myocardial infarction (MI). However, the combination of ET and -blocker therapy, as well as its effectiveness in patients with a more compromised HRR (12bpm), has been under-studied. Male patients (n=64) post-MI were divided: Training+-blocker (n=19), Training (n=15), -blocker (n=11) and Control (n=19). Participants performed an ergometric test before and after 3months of intervention. HRR was obtained during 5min of recovery and corrected by the cardiac reserve (HRRcorrCR). Compared to pre-intervention, HRRcorrCR was significantly increased during the 1st and 2nd minutes of recovery in the Training+-blocker group (70<bold></bold>5% and 37<bold></bold>5%, respectivelyen
dc.description.abstractP<0<bold></bold>05). A significant improvement, lasting from the 1st to the 4th minute of recovery, was also observed in the Training group (47%, 50%, 25% and 8<bold></bold>7%, respectivelyen
dc.description.abstractP<0<bold></bold>05). In contrast, the -blocker group showed a reduction in HRRcorrCR during the 2nd and 3rd minutes of recovery (-21<bold></bold>2% and -16<bold></bold>3%, respectivelyen
dc.description.abstractP<0<bold></bold>05). In addition, interventions involving ET (Training+b, Training) were significantly more effective in patients with a pre-intervention HRR12bpm than for patients with HRR>12bpm. Combination of -blocker therapy with ET does not compromise the effect of training and instead promotes HRR and aerobic capacity improvement. In addition, this combination is particularly beneficial for individuals presenting with a more compromised HRR. However, chronic administration of -blocker therapy alone did not promote improvement in HRR or aerobic capacity.en
dc.description.affiliationSanto Amaro Univ UNISA, Lab Exercise Physiol & Cardiac Rehabil GERFE, Dept Med & Physiotherapy, Sao Paulo, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Pulm Funct & Clin Exercise Physiol Unit SEFICE, Div Resp, Sao Paulo, Brazil
dc.description.affiliationIbirapuera Univ UNIB, Dept Rehabil & Funct Capac, Sch Physiotherapy, Sao Paulo, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Pulm Funct & Clin Exercise Physiol Unit SEFICE, Div Resp, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent351-359
dc.identifierhttp://dx.doi.org/10.1111/cpf.12420
dc.identifier.citationClinical Physiology And Functional Imaging. Hoboken, v. 38, n. 3, p. 351-359, 2018.
dc.identifier.doi10.1111/cpf.12420
dc.identifier.issn1475-0961
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55594
dc.identifier.wosWOS:000430103100002
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofClinical Physiology And Functional Imaging
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectautonomic functionen
dc.subjectbeta-blockeren
dc.subjectcardiac rehabilitationen
dc.subjectexercise testingen
dc.subjectexercise trainingen
dc.subjectheart diseaseen
dc.subjectheart rate recoveryen
dc.titleHeart rate recovery improvement in patients following acute myocardial infarction: exercise training, -blocker therapy or bothen
dc.typeinfo:eu-repo/semantics/article
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