Predictors of Cognitive and Functional Decline in Patients With Alzheimer Disease Dementia From Brazil

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dc.citation.issue3
dc.citation.volume30
dc.contributor.authorOliveira, Fabricio F. [UNIFESP]
dc.contributor.authorChen, Elizabeth S. [UNIFESP]
dc.contributor.authorSmith, Marilia C. [UNIFESP]
dc.contributor.authorBertolucci, Paulo H. F. [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-08-14T13:44:21Z
dc.date.available2020-08-14T13:44:21Z
dc.date.issued2016
dc.description.abstractLittle is known on how risk factors for Alzheimer disease (AD) dementia affect disease progression, much less for populations with low mean schooling, whereas the transcription of APOE may be regulated by nongenetic factors. In this 44-month cohort study, 214 consecutive outpatients with late-onset AD were assessed for rates of cognitive and functional decline by way of Clinical Dementia Rating and Mini-Mental State Examination (MMSE) scores, keeping blinded assessment of APOE haplotypes. Subjects were evaluated for sex, schooling, age of dementia onset, and cerebrovascular risk factors (including Framingham risk scores). Of the 214 patients, there were 146 (68.2%) women and 113 (52.8%) APOE4+ carriers. The mean age of AD onset was 73.4 +/- 6.5 years-old, negatively correlated with time to Clinical Dementia Rating >1.0 (=-0.132en
dc.description.abstract<0.001), MMSE=20 (=-0.105en
dc.description.abstract<0.001), and MMSE=15 (=-0.124en
dc.description.abstract=0.003), more significantly for women and APOE4+ carriers. Mean schooling was 4.18 +/- 3.7 years, correlated with time to MMSE=20 and MMSE=15 for women and APOE4+ carriers. Body mass index was correlated with time to MMSE=20 only for men (=0.006). The 10-year coronary heart disease risk was correlated with time to MMSE=20 only for APOE4+ carriers (=0.015). These outcomes suggest interactions among genomic effects of cognitive reserve, cerebral perfusion, and hormonal changes over mechanisms of neurodegeneration.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Escola Paulista Med, Dept Neurol & Neurosurg, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Escola Paulista Med, Dept Morphol & Genet, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Escola Paulista Med, Dept Neurol & Neurosurg, Rua Botucatu 740, BR-04023900 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Escola Paulista Med, Dept Morphol & Genet, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES-Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
dc.description.sponsorshipCNPq Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
dc.description.sponsorshipFAPESP
dc.format.extent243-250
dc.identifierhttp://dx.doi.org/10.1097/WAD.0000000000000117
dc.identifier.citationAlzheimer Disease & Associated Disorders. Philadelphia, v. 30, n. 3, p. 243-250, 2016.
dc.identifier.doi10.1097/WAD.0000000000000117
dc.identifier.issn0893-0341
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57616
dc.identifier.wosWOS:000383914600008
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAlzheimer Disease & Associated Disorders
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectagingen
dc.subjectAlzheimer diseaseen
dc.subjecteducational statusen
dc.subjectcognitionen
dc.subjectdementiaen
dc.subjectrisk factorsen
dc.titlePredictors of Cognitive and Functional Decline in Patients With Alzheimer Disease Dementia From Brazilen
dc.typeinfo:eu-repo/semantics/article
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