Genetic Variants in SNCA and the Risk of Sporadic Parkinson's Disease and Clinical Outcomes: A Review

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dc.contributor.authordas Chagas Campelo, Clarissa Loureiro
dc.contributor.authorSilva, Regina Helena [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-17T14:03:35Z
dc.date.available2020-07-17T14:03:35Z
dc.date.issued2017
dc.description.abstractThere is increasing evidence of the contribution of genetic susceptibility to the etiology of Parkinson's disease ( PD). Genetic variations in the SNCA gene are well established by linkage and genome-wide association studies. Positive associations of single nucleotide polymorphisms (SNPs) in SNCA and increased risk for PD were found. However, the role of SNCA variants in individual traits or phenotypes of PD is unknown. Here, we reviewed the current literature and identified 57 studies, performed in fourteen different countries, that investigated SNCA variants and susceptibility to PD. We discussed the findings based on environmental factors, history of PD, clinical outcomes, and ethnicity. In conclusion, SNPs within the SNCA gene can modify the susceptibility to PD, leading to increased or decreased risk. The risk associations of some SNPs varied among samples. Of notice, no studies in South American or African populations were found. There is little information about the effects of these variants on particular clinical aspects of PD, such as motor and nonmotor symptoms. Similarly, evidence of possible interactions between SNCA SNPs and environmental factors or disease progression is scarce. There is a need to expand the clinical applicability of these data as well as to investigate the role of SNCA SNPs in populations with different ethnic backgrounds.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Physiol, Memory Studies Lab, Natal, RN, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Behav Neurosci Lab, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pharmacol, Behav Neurosci Lab, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte (FAPERN/PRONEX)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipIDCNPq: 402054/2010-5
dc.description.sponsorshipIDFAPESP: 2015/12308-5
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1155/2017/4318416
dc.identifier.citationParkinsons Disease. London, v. , p. -, 2017.
dc.identifier.doi10.1155/2017/4318416
dc.identifier.fileWOS000406211700001.pdf
dc.identifier.issn2090-8083
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55513
dc.identifier.wosWOS:000406211700001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofParkinsons Disease
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleGenetic Variants in SNCA and the Risk of Sporadic Parkinson's Disease and Clinical Outcomes: A Reviewen
dc.typeinfo:eu-repo/semantics/article
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