Carbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditions

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dc.citation.issue11
dc.citation.volume8
dc.contributor.authorCaris, Aline Venticinque [UNIFESP]
dc.contributor.authorSilva, Edgar Tavares da [UNIFESP]
dc.contributor.authorSantos, Samile Amorim dos [UNIFESP]
dc.contributor.authorLira, Fabio Santos
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorSantos, Ronaldo Vagner Thomatieli dos [UNIFESP]
dc.coverageBasel
dc.date.accessioned2020-07-31T12:47:25Z
dc.date.available2020-07-31T12:47:25Z
dc.date.issued2016
dc.description.abstractIntroduction: Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate the effect of carbohydrate supplementation on cytokines and cellular damage markers after exercise under hypoxic conditions at a simulated altitude of 4200 m. Methods: Seven adult male volunteers who exercised for 60 min at an intensity of 50% VO2Peak were randomly evaluated under three distinct conditionsen
dc.description.abstractnormoxia, hypoxia and hypoxia + carbohydrate supplementation. Blood samples were collected at rest, at the end of exercise and after 60 min of recovery. To evaluate hypoxia + carbohydrate supplementation, volunteers received a solution of 6% carbohydrate (maltodextrin) or a placebo (strawberry-flavored Crystal Light (R)en
dc.description.abstractKraft Foods, Northfield, IL, USA) every 20 min during exercise and recovery. Statistical analyses comprised analysis of variance, with a one-way ANOVA followed by the Tukey post hoc test with a significance level of p < 0.05. Results: Under normoxic and hypoxic conditions, there was a significant increase in the concentration of IL-6 after exercise and after recovery compared to at rest (p < 0.05), while in the hypoxia + carbohydrate group, there was a significant increase in the concentration of IL-6 and TNF-alpha after exercise compared to at rest (p < 0.05). Furthermore, under this condition, TNF-alpha, IL-2 and the balance of IL-2/IL-4 were increased after recovery compared to at rest (p < 0.05). Conclusion: We conclude that carbohydrate supplementation modified the IL-6 and TNF-alpha serum concentrations and shifted the IL-2/IL-4 balance towards Th1 in response without glycemic, glutaminemia and cell damage effects.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, BR-04021001 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, BR-11060001 Santos, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Phys Educ, BR-19060900 Presidente Prudente, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, BR-04021001 Sao Paulo, Brazil
dc.description.affiliationUnifespDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo 04021-001, Brazil
dc.description.affiliationUnifespDepartment of Bioscience, Universidade Federal de São Paulo, Santos 11060-001, Brazil
dc.description.affiliationUnifespDepartment of Physiology, Universidade Federal de São Paulo, São Paulo 04021-001, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipAssociação Fundo de Incentivo à Psicofarmacologia (AFIP)
dc.description.sponsorshipIDFAPESP: 2013/01324-4
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.3390/nu8110706
dc.identifier.citationNutrients. Basel, v. 8, n. 11, p. -, 2016.
dc.identifier.doi10.3390/nu8110706
dc.identifier.fileWOS000388666400041.pdf
dc.identifier.issn2072-6643
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56823
dc.identifier.wosWOS:000388666400041
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofNutrients
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectsupplementationen
dc.subjectcarbohydrateen
dc.subjecthypoxiaen
dc.subjectexerciseen
dc.subjectimmune systemen
dc.subjectIL-2/IL-4en
dc.titleCarbohydrate Supplementation Influences Serum Cytokines after Exercise under Hypoxic Conditionsen
dc.typeinfo:eu-repo/semantics/article
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