Family history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese children

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dc.citation.issue4
dc.citation.volume62
dc.contributor.authorStrufaldi, Maria Wany Louzada [UNIFESP]
dc.contributor.authorSouza, Fabíola Isabel Suano de [UNIFESP]
dc.contributor.authorPuccini, Rosana Fiorini [UNIFESP]
dc.contributor.authorFranco, Maria do Carmo Pinho [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-08-14T13:44:22Z
dc.date.available2020-08-14T13:44:22Z
dc.date.issued2016
dc.description.abstractObjective: To describe the values of non-HDL cholesterol (NHDL-c) and the frequency of a family history of early cardiovascular disease (family HCVD) in healthy prepubescent children. Analyze the association between NHDL-c and family HCVD, and possible associations with other risk factors for cardiovascular disease (CVD). METHOD: Cross-sectional study including 269 prepubescent (aged 6-10 years) schoolchildren with a normal body mass index (+1SD<BMI>-2SD). Data collected: Family HCVD; weight and height, waist circumference and systemic blood pressure; lipid profile (total cholesterol TC, HDL-c, triglycerides and LDL-c), NHDL-c calculation (CT-HDL-c, cut-off = 145 mg/dL) and insulin resistance (HOMA-IR). RESULTS: High levels were found for NHDL-c in 10 (3.7%) of these schoolchildren, and family early HCVD was found in 46 (17.1%) of them. There was a weak association between family HCVD and NHDL-c (Cramer’s-V-test = 0.120; p=0.050). Among the children with NHDL-c≥145 mg/dL, 4 (40%) have family HCVD. The presence of family HCVD was not associated with the variables being studied. The variables independently associated with NHDL-c ≥ 145 mg/dL were: HOMA-IR (OR=1.7; 95CI 1.1-2.6) and diastolic blood pressure (OR=1.1; 95CI 1.02-1.2). CONCLUSION: NHDL-c values were associated with blood pressure and insulin resistance. Family HCVD was not associated with other classic risk factors for CVD, even though the frequency found was five times higher than that of high NHDL-c.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationFac Med ABC, Dept Pediat, Santo Andre, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Physiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Physiol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 08/58963-0
dc.description.sponsorshipIDFAPESP: 07/58044-2
dc.format.extent347-352
dc.identifierhttps://dx.doi.org/10.1590/1806-9282.62.04.347
dc.identifier.citationRevista Da Associacao Medica Brasileira. Sao Paulo, v. 62, n. 4, p. 347-352, 2016.
dc.identifier.doi10.1590/1806-9282.62.04.347
dc.identifier.fileWOS000380848800011.pdf
dc.identifier.issn0104-4230
dc.identifier.scieloS0104-42302016000400347
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57629
dc.identifier.wosWOS:000380848800011
dc.language.isopor
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDyslipidemiasen
dc.subjectCardiovascular diseasesen
dc.subjectChilden
dc.subjectPrimary preventionen
dc.titleFamily history of cardiovascular disease and non-HDL cholesterol in prepubescent non-obese childrenen
dc.typeinfo:eu-repo/semantics/article
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