Behavioral effects of MK-801 on reserpine-treated mice

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dc.contributor.authorDutra, R. C.
dc.contributor.authorAndreazza, A. P.
dc.contributor.authorAndreatini, R.
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorVital, Maria ABF [UNIFESP]
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:20Z
dc.date.available2016-01-24T12:33:20Z
dc.date.issued2002-04-01
dc.description.abstractThe effects of dizocilpine (MK-801), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, were studied on dopamine-related behaviors induced by reserpine treatments. This study focuses on behavioral syndromes that may used as models for Parkinson's disease, or tardive dyskinesia, and its response after glutamatergic blockage. Reserpine (1 mg/kg), administered once every other day for 4 days, produced increases in orofacial dyskinesia, tongue protrusion and vacuous chewing in mice, which are signs indicative of tardive dyskinesia. Reserpine also produced tremor and catalepsy, which are signs suggestive of Parkinson's disease. MK-801 (0.1 mg/kg), administered 30 min before the observation test, prevented the vacuous chewing movements., tongue protrusions and catalepsy induced by reserpine. However, MK-801 injection produced a significant increase of tremor in reserpine-treated mice. Reserpine (1 mg/kg), administered 90 min before the test and followed by apomophine injection (0.1 mg/kg) 5 min before the test, did not produce oral dyskinesia in mice. On the other hand, reserpine induced increases in tremor and catalepsy compared to control mice. MK-801 (0.1 mg/kg) administration attenuated the catalepsy and tremor induced by reserpine. Pretreatment with reserpine (1 mg/kg) 24 h before the observation test produced increases in vacuous chewing movements and tongue protrusion, as well as increases in tremor and catalepsy, whereas MK-801 (0.1 mg/kg) injection 90 min before the test reversed the effects of reserpine, These results show that reserpine produces different and abnormal movements, which are related to dose and schedule employed and can be considered as parkinsonian-like and tardive dsykinesia signs. the glutamatergic blockage produced by NMDA can restore these signs, such as vacuous chewing movements, tongue protrusions, catalepsy and tremor according to the employed model. (C) 2001 Elsevier Science Inc. All rights reserved.en
dc.description.affiliationUniv Fed Parana, Dept Pharmacol, Ctr Politecn, SNC,Lab Fisiol & Farmacol, BR-81531990 Curitiba, Parana, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent487-495
dc.identifierhttp://dx.doi.org/10.1016/S0278-5846(01)00295-0
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 26, n. 3, p. 487-495, 2002.
dc.identifier.doi10.1016/S0278-5846(01)00295-0
dc.identifier.issn0278-5846
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26818
dc.identifier.wosWOS:000174698300011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectcatalepsyen
dc.subjectMK-801en
dc.subjectreserpineen
dc.subjecttongue protrusionsen
dc.subjecttremoren
dc.subjectvacuous chewingen
dc.titleBehavioral effects of MK-801 on reserpine-treated miceen
dc.typeinfo:eu-repo/semantics/article
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