Amino acid and monoamine alterations in the cerebral cortex and hippocampus of mice submitted to ricinine-induced seizures

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dc.contributor.authorFerraz, A. C.
dc.contributor.authorAnselmo-Franci, J. A.
dc.contributor.authorPerosa, SR
dc.contributor.authorCastro-Neto, E. F. de
dc.contributor.authorBellissimo, M. I.
dc.contributor.authorOliveira, B. H. de
dc.contributor.authorCavalheiro, E. A.
dc.contributor.authorNaffah-Mazzacoratti, MDG
dc.contributor.authorDa Cunha, C.
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionFac Odontol
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:33:26Z
dc.date.available2016-01-24T12:33:26Z
dc.date.issued2002-07-01
dc.description.abstractThe alkaloid ricinine isolated from the plant Ricinus communis, when administered to mice at high doses, induces clonic seizures accompanied by electroencephalographic alterations in the cerebral cortex and hippocampus. the lethal nature of ricinine-induced seizures is considered to be a good model for the study of the events that cause death during clonic seizures, particularly those related to respiratory spasms. the initial signs (pre-seizure period) were marked by exophthalmus and decreased locomotor behavior. Animals killed during the preseizure period presented an increased utilization rate (HVA/DA) of dopamine (DA), an increased concentration of noradrenaline (NA), and a decreased concentration of glutamate (Glu), glutamine (Gln), taurine (Tau), and serotonin (5-HT) in the cerebral cortex. the seizure period is characterized by the occurrence of hind limb myoclonus and respiratory spasms, which are followed by death. Alterations in the cerebral cortex concentration of these neurotransmitters persisted during the seizure period. These alterations are only partially observed in the hippocampus, mainly during the seizure period. the present results suggest that an increased release of Glu in the cerebral cortex can be implicated in the genesis of the ricinine-induced seizure and that it triggers many anticonvulsive mechanisms, like the release of Tau, DA, 5-HT, and NA. (C) 2002 Elsevier Science Inc. All rights reserved.en
dc.description.affiliationUniv Fed Parana, SNC, Lab Fis & Farmacol, Dept Fisiol, BR-81531990 Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Parana, Dept Farmacol, BR-81531990 Curitiba, Parana, Brazil
dc.description.affiliationFac Odontol, Dept Morfol Estomatol & Fisiol, BR-14040904 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, EPM, Disciplinas Bioquim & Neurol Expt, São Paulo, SP, Brazil
dc.description.affiliationUniv Fed Parana, Dept Quim, BR-80060000 Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Disciplinas Bioquim & Neurol Expt, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent779-786
dc.identifierhttp://dx.doi.org/10.1016/S0091-3057(02)00750-5
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 72, n. 4, p. 779-786, 2002.
dc.identifier.doi10.1016/S0091-3057(02)00750-5
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26910
dc.identifier.wosWOS:000176990600003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectricinineen
dc.subjectcerebral cortexen
dc.subjecthippocampusen
dc.subjectseizuresen
dc.subjectamino acidsen
dc.subjectmonoaminesen
dc.subjectmiceen
dc.titleAmino acid and monoamine alterations in the cerebral cortex and hippocampus of mice submitted to ricinine-induced seizuresen
dc.typeinfo:eu-repo/semantics/article
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