Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

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dc.citation.issue4
dc.citation.volume32
dc.contributor.authorMackay, Alan
dc.contributor.authorBurford, Anna
dc.contributor.authorCarvalho, Diana
dc.contributor.authorIzquierdo, Elisa
dc.contributor.authorFazal-Salom, Janat
dc.contributor.authorTaylor, Kathryn R.
dc.contributor.authorBjerke, Lynn
dc.contributor.authorClarke, Matthew
dc.contributor.authorVinci, Mara
dc.contributor.authorNandhabalan, Meera
dc.contributor.authorTemelso, Sara
dc.contributor.authorPopov, Sergey
dc.contributor.authorMolinari, Valeria
dc.contributor.authorRaman, Pichai
dc.contributor.authorWaanders, Angela J.
dc.contributor.authorHan, Harry J.
dc.contributor.authorGupta, Saumya
dc.contributor.authorMarshall, Lynley
dc.contributor.authorZacharoulis, Stergios
dc.contributor.authorVaidya, Sucheta
dc.contributor.authorMandeville, Henry C.
dc.contributor.authorBridges, Leslie R.
dc.contributor.authorMartin, Andrew J.
dc.contributor.authorAl-Sarraj, Safa
dc.contributor.authorChandler, Christopher
dc.contributor.authorNg, Ho-Keung
dc.contributor.authorLi, Xingang
dc.contributor.authorMu, Kun
dc.contributor.authorTrabelsi, Saoussen
dc.contributor.authorH'mida-Ben Brahim, Dorra
dc.contributor.authorKisljakov, Alexei N.
dc.contributor.authorKonovalov, Dmitry M.
dc.contributor.authorMoore, Andrew S.
dc.contributor.authorMontero Carcaboso, Angel
dc.contributor.authorSunol, Mariona
dc.contributor.authorde Torres, Carmen
dc.contributor.authorCruz, Ofelia
dc.contributor.authorMora, Jaume
dc.contributor.authorShats, Ludmila I.
dc.contributor.authorStavale, Joao N. [UNIFESP]
dc.contributor.authorBidinotto, Lucas T.
dc.contributor.authorReis, Rui M.
dc.contributor.authorEntz-Werle, Natacha
dc.contributor.authorFarrell, Michael
dc.contributor.authorCryan, Jane
dc.contributor.authorCrimmins, Darach
dc.contributor.authorCaird, John
dc.contributor.authorPears, Jane
dc.contributor.authorMonje, Michelle
dc.contributor.authorDebily, Marie-Anne
dc.contributor.authorCastel, David
dc.contributor.authorGrill, Jacques
dc.contributor.authorHawkins, Cynthia
dc.contributor.authorNikbakht, Hamid
dc.contributor.authorJabado, Nada
dc.contributor.authorBaker, Suzanne J.
dc.contributor.authorPfister, Stefan M.
dc.contributor.authorJones, David T. W.
dc.contributor.authorFouladi, Maryam
dc.contributor.authorvon Bueren, Andre O.
dc.contributor.authorBaudis, Michael
dc.contributor.authorResnick, Adam
dc.contributor.authorJones, Chris
dc.coverageCambridge
dc.date.accessioned2020-08-04T13:39:52Z
dc.date.available2020-08-04T13:39:52Z
dc.date.issued2017
dc.description.abstractWe collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of > 1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification.en
dc.description.affiliationInst Canc Res, Div Mol Pathol, London, England
dc.description.affiliationInst Canc Res, Div Canc Therapeut, London, England
dc.description.affiliationStanford Univ, Sch Med, Dept Neurol, Stanford, CA USA
dc.description.affiliationUniv Hosp Wales, Dept Cellular Pathol, Cardiff, S Glam, Wales
dc.description.affiliationChildrens Hosp Philadelphia, Ctr Data Driven Discovery Biomed D3b, Philadelphia, PA USA
dc.description.affiliationChildrens Hosp Philadelphia, Div Neurosurg, Philadelphia, PA USA
dc.description.affiliationChildrens Hosp Philadelphia, Div Oncol, Philadelphia, PA USA
dc.description.affiliationUniv Zurich, Swiss Inst Bioinformat, Inst Mol Life Sci, Zurich, Switzerland
dc.description.affiliationRoyal Marsden Hosp, Children & Young Peoples Unit, Pediat Oncol Drug Dev Team, Sutton, Surrey, England
dc.description.affiliationRoyal Marsden Hosp, Dept Radiotherapy, Sutton, Surrey, England
dc.description.affiliationSt Georges Hosp NHS Trust, Dept Cellular Pathol, London, England
dc.description.affiliationSt Georges Hosp NHS Trust, Dept Neurosurg, London, England
dc.description.affiliationKings Coll Hosp London, Dept Neuropathol, London, England
dc.description.affiliationKings Coll Hosp London, Dept Neurosurg, London, England
dc.description.affiliationChinese Univ Hong Kong, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China
dc.description.affiliationShandong Univ, Qilu Hosp, Dept Neurosurg, Jinan, Shandong, Peoples R China
dc.description.affiliationShandong Univ, Brain Sci Res Inst, Jinan, Shandong, Peoples R China
dc.description.affiliationShandong Univ, Sch Med, Dept Pathol, Jinan, Shandong, Peoples R China
dc.description.affiliationFarhat Hached Hosp, Dept Cytogenet & Reprod Biol, Sousse, Tunisia
dc.description.affiliationMorozov Childrens Hosp, Dept Pathol, Moscow, Russia
dc.description.affiliationDmitrii Rogachev Res & Clin Ctr Pediat Hematol On, Dept Pathol, Moscow, Russia
dc.description.affiliationUniv Queensland, UQ Child Hlth Res Ctr, Brisbane, Qld, Australia
dc.description.affiliationChildrens Hlth Queensland Hosp & Hlth Serv, Oncol Serv Grp, Brisbane, Qld, Australia
dc.description.affiliationUniv Queensland, Diamantina Inst, Translat Res Inst, Brisbane, Qld, Australia
dc.description.affiliationInst Recerca Sant Joan de Deu, Barcelona, Spain
dc.description.affiliationSt Petersburg State Pediat Med Univ, Div Oncol Pediat Oncol & Radiotherapy, St Petersburg, Russia
dc.description.affiliationUniv Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationBarretos Canc Hosp, Mol Oncol Res Ctr, Sao Paulo, Brazil
dc.description.affiliationUniv Minho, Med Sch, Life & Hlth Sci Res Inst ICVS, Braga, Portugal
dc.description.affiliationICVS 3Bs PT Govt Associate Lab, Braga, Portugal
dc.description.affiliationCtr Hosp Reg, Pediat Oncohemato Pediat 3, Strasbourg, France
dc.description.affiliationUniv Hautepierre, Strasbourg, France
dc.description.affiliationBeaumont Hosp, Histopathol Dept, Dublin, Ireland
dc.description.affiliationTemple St Childrens Univ Hosp, Dept Neurosurg, Dublin, Ireland
dc.description.affiliationOur Ladys Childrens Hosp, Dept Paediat Oncol, Dublin, Ireland
dc.description.affiliationInst Gustav Roussy, Dept Cancerol Enfant & Adolescent, Villejuif, France
dc.description.affiliationHosp Sick Children, Pediat Lab Med, Toronto, ON, Canada
dc.description.affiliationMcGill Univ, Dept Pediat, Montreal, PQ, Canada
dc.description.affiliationSt Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN USA
dc.description.affiliationGerman Canc Res Ctr, Div Pediat Neurooncol, Heidelberg, Germany
dc.description.affiliationUniv Heidelberg Hosp, Dept Pediat Hematol & Oncol, Heidelberg, Germany
dc.description.affiliationCincinnati Childrens Hosp, Canc & Blood Dis Inst, Dept Pediat, Cincinnati, OH USA
dc.description.affiliationUniv Med Ctr Goettingen, Div Pediat Hematol & Oncol, Dept Pediat, Gottingen, Germany
dc.description.affiliationUniv Hosp Geneva, Div Pediat Hematol & Oncol, Dept Pediat & Adolescent Med, Geneva, Switzerland
dc.description.affiliationUniv Geneva, Fac Med, CANSEARCH Res Lab, Dept Pediat, Geneva, Switzerland
dc.description.affiliationNCT Heidelberg KiTZ, Hopp Childrens Canc Ctr, Heidelberg, Germany
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCancer Research UK
dc.description.sponsorshipCRIS Cancer Foundation
dc.description.sponsorshipAbbie's Army
dc.description.sponsorshipDIPG Collaborative
dc.description.sponsorshipCure Starts Now Foundation
dc.description.sponsorshipMcKenna Claire Foundation
dc.description.sponsorshipLyla Nsouli Foundation
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipDragon Master Foundation
dc.description.sponsorshipKortney Rose Foundation
dc.description.sponsorshipMusella Foundation For Brain Tumor Research Information
dc.description.sponsorshipGray Matters Foundation
dc.description.sponsorshipPediatric Brain Tumor Foundation
dc.description.sponsorshipINSTINCT network - Brain Tumour Charity
dc.description.sponsorshipGreat Ormond Street Children's Charity
dc.description.sponsorshipChildren with Cancer UK
dc.description.sponsorshipNHS
dc.description.sponsorshipICR
dc.description.sponsorshipSao Paulo Research Foundation
dc.description.sponsorshipChristopher's Smile
dc.description.sponsorshipIDFAPESP: 2011/08523-7
dc.description.sponsorshipIDFAPESP: 2012/08287-4
dc.format.extent520-+
dc.identifierhttp://dx.doi.org/10.1016/j.ccell.2017.08.017
dc.identifier.citationCancer Cell. Cambridge, v. 32, n. 4, p. 520-+, 2017.
dc.identifier.doi10.1016/j.ccell.2017.08.017
dc.identifier.fileWOS000412566900014.pdf
dc.identifier.issn1535-6108
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57157
dc.identifier.wosWOS:000412566900014
dc.language.isoeng
dc.publisherCell Press
dc.relation.ispartofCancer Cell
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleIntegrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Gliomaen
dc.typeinfo:eu-repo/semantics/article
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