Antibody response against plasmid-encoded toxin (Pet) and the protein involved in intestinal colonization (Pic) in children with diarrhea produced by enteroaggregative Escherichia coli

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dc.contributor.authorBellini, E. M.
dc.contributor.authorElias Junior, Waldir Pereira [UNIFESP]
dc.contributor.authorGomes, Tania Aparecida Tardelli [UNIFESP]
dc.contributor.authorTanaka, T. L.
dc.contributor.authorTaddei, C. R.
dc.contributor.authorHuerta, R.
dc.contributor.authorNavarro-Garcia, F.
dc.contributor.authorMartinez, M. B.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInst Butantan
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCINVESTAV
dc.date.accessioned2016-01-24T12:37:36Z
dc.date.available2016-01-24T12:37:36Z
dc.date.issued2005-02-01
dc.description.abstractEnteroaggregative Escherichia eoli (EAEC) is an emerging cause of pediatric and adult travellers diarrhea. the mechanism by which EAEC induce diarrhea is not completely known. Two serine protease autotransporter proteins, named Pet and Pic have been identified in EAEC strains. Pet has enterotoxic and cytotoxic activities, while the role of Pic in pathogenesis may lie on its mucinolytic activity. Little is known about Pet and Pic biological activities in vivo. in this study the antibody responses against these autotransporter proteins in convalescent children is investigated. Fifteen (83%) children showed specific antibodies against Pet or Pic in their sera. IgG and IgM antibodies were the main isotype found. Specific antibodies against Pic, but not against Pet, were detected in sera from age-matched control group. These data show that specific anti-Pet and anti-Pic antibodies are produced during the course of a natural EAEC infection in children. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Dept Microbiol, Inst Ciencias Biomed, São Paulo, Brazil
dc.description.affiliationInst Butantan, Lab Especial Microbiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508900 São Paulo, Brazil
dc.description.affiliationCINVESTAV, IPN, Dept Cell Biol, Mexico City 14000, DF, Mexico
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent259-264
dc.identifierhttp://dx.doi.org/10.1016/j.femsim.2004.08.008
dc.identifier.citationFems Immunology and Medical Microbiology. Amsterdam: Elsevier B.V., v. 43, n. 2, p. 259-264, 2005.
dc.identifier.doi10.1016/j.femsim.2004.08.008
dc.identifier.issn0928-8244
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28119
dc.identifier.wosWOS:000226989800019
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFems Immunology and Medical Microbiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectEAECen
dc.subjectPeten
dc.subjectPicen
dc.subjectantibody responseen
dc.subjectIgGen
dc.subjectIgMen
dc.subjectIgAen
dc.subjectdiarrheaen
dc.subjectChildrenen
dc.titleAntibody response against plasmid-encoded toxin (Pet) and the protein involved in intestinal colonization (Pic) in children with diarrhea produced by enteroaggregative Escherichia colien
dc.typeinfo:eu-repo/semantics/article
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