A possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumours

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dc.contributor.authorSouza Queiroz, Karla Cristiana de
dc.contributor.authorZambuzzi, Willian Fernando
dc.contributor.authorSouza, Ana Carolina Santos de
dc.contributor.authorSilva, Rodrigo Augusto da
dc.contributor.authorMachado, Daisy
dc.contributor.authorJusto, Giselle Zenker
dc.contributor.authorCarvalho, Hernandes F.
dc.contributor.authorPeppelenbosch, Maikel P.
dc.contributor.authorFerreira, Carmen Verissima
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Groningen
dc.date.accessioned2016-01-24T13:49:17Z
dc.date.available2016-01-24T13:49:17Z
dc.date.issued2007-12-08
dc.description.abstractRiboflavin is a potent photosensitizer as well as part of the vitamin B complex. Recently we demonstrated that the products generated by irradiation of riboflavin have potential as anti-leukaemic therapy. the possible action, however, of the riboflavin photoproducts in solid cancers has not been addressed. Hence, we investigated the effects of irradiated riboflavin on androgen-independent human prostate cancer cells (PC3), a known model for solid tumour cells with an exceptional resistance to therapy. Our results show that riboflavin photoproducts are cytotoxic to these cells in a FasL-Fas-dependent manner. Furthermore, irradiated riboflavin inhibited matrix-degrading proteases, caused downregulation of VEGF and upregulation of TIMP1 suggesting anti-metastatic potential. Together, these results show that the anti-neoplastic action of riboflavin photoproducts is not limited to haematological malignancies, warranting clinical studies in solid tumours. (c) 2007 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, Dept Bioquim, BR-13081970 Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Biol Celular, BR-13081970 Campinas, SP, Brazil
dc.description.affiliationUniv Groningen, Med Ctr, Dept Cell Biol, Groningen, Netherlands
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Bioquim, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent126-134
dc.identifierhttp://dx.doi.org/10.1016/j.canlet.2007.08.024
dc.identifier.citationCancer Letters. Clare: Elsevier B.V., v. 258, n. 1, p. 126-134, 2007.
dc.identifier.doi10.1016/j.canlet.2007.08.024
dc.identifier.issn0304-3835
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30208
dc.identifier.wosWOS:000251407200015
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCancer Letters
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectprostate canceren
dc.subjectriboflavinen
dc.subjectapoptosisen
dc.titleA possible anti-proliferative and anti-metastatic effect of irradiated riboflavin in solid tumoursen
dc.typeinfo:eu-repo/semantics/article
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