Conditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substitute

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dc.citation.issue7
dc.citation.volume104
dc.contributor.authorMorandim-Giannetti, Andreia de Araujo
dc.contributor.authorSilva, Rosianne Cristina
dc.contributor.authorMagalhaes Junior, Octaviano [UNIFESP]
dc.contributor.authorSchor, Paulo [UNIFESP]
dc.contributor.authorBersanetti, Patricia Alessandra [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:43Z
dc.date.available2020-07-31T12:47:43Z
dc.date.issued2016
dc.description.abstractHydrogels are polymeric materials with numerous medical and biological applications because of their physicochemical properties. In this context, the conditions were defined for obtaining a hydrogel with characteristics similar to the vitreous humor using polyvinyl alcohol (PVA) and trisodium trimetaphosphate (STMP). The concentration of PVA (X-1), PVA/STMP ratio (X-2), and initial pH (X-3) were modified, and their effect was analyzed in terms of the refractive index (Y-1), density (Y-2), dynamic viscosity (Y-3), and final pH (Y-4). The results demonstrated that X-1 interferes with Y-1, Y-2, and Y-3, and X-2 interferes with Y-2 and Y-3. The best condition for obtaining a hydrogel with characteristics similar to the vitreous humor was 4.2586% PVA (wt/wt), STMP/PVA ratio of 1:6.8213 (wt/wt), and initial pH of 9.424. DSC, ATR-FTIR, swelling degree, and AFM analysis confirmed the PVA reticulation with STMP. Furthermore, STMP increased the glass transition temperature and decreased the water uptake of approximate to 50% of the hydrogels, which can be explained by the crosslinking of PVA chains. Infrared spectroscopy revealed a decrease of hydroxyl bonds and confirmed the reticulation between PVA and STMP. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1386-1395, 2016.en
dc.description.affiliationCtr Univ FEI, Dept Engn Quim, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Oftalmol & Ciencias Visuais, Escola Paulista Med, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Informat Saude, Escola Paulista Med, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUnifespDepartamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifespDepartamento de Informática em Saúde, Escola Paulista de Medicina, Universidade Federal de São Paulo, UNIFESP, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversity Center of FEI, Department of Ophthalmology and Visual Sciences of the Federal University of Sao Paulo (UNIFESP)
dc.description.sponsorshipIDFAPESP: 2012/07343-8
dc.format.extent1386-1395
dc.identifierhttp://dx.doi.org/10.1002/jbm.b.33473
dc.identifier.citationJournal Of Biomedical Materials Research Part B-Applied Biomaterials. Hoboken, v. 104, n. 7, p. 1386-1395, 2016.
dc.identifier.doi10.1002/jbm.b.33473
dc.identifier.issn1552-4973
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57034
dc.identifier.wosWOS:000383773400013
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Biomedical Materials Research Part B-Applied Biomaterials
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjecthydrogelen
dc.subjectcrosslinkingen
dc.subjectpolyvinylalcoholen
dc.subjectvitreous substituteen
dc.titleConditions for obtaining polyvinyl alcohol/trisodium trimetaphosphate hydrogels as vitreous humor substituteen
dc.typeinfo:eu-repo/semantics/article
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