The anxiolytic effect of pregnancy in rats is reversed by finasteride

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dc.contributor.authorFaturi, Claudia de Brito
dc.contributor.authorTeixeira-Silva, Flavia
dc.contributor.authorLeite, Jose Roberto
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:34Z
dc.date.available2016-01-24T12:41:34Z
dc.date.issued2006-11-01
dc.description.abstractSeveral studies have shown the influence of the oestrous cycle on anxiety levels and the important role of progesterone in this effect. the metabolism of this steroid hormone yields neuroactive steroids among them allopregnatiolone (alloP) and allotetrahydrodeoxycorticosterone (alloTHDOC), which bind to GABA(A) receptors and have anxiolytic effects. Considering that during pregnancy there is an increase in levels of both progesterone and its metabolites, the main objectives of this work were: (1) to assess changes in anxiety levels during pregnancy and (2) to verify the role of alloP and alloTHDOC in this process using finasteride, an inhibitor of 5 alpha-reductase, the enzyme responsible for their synthesis.The results showed a significant reduction in anxiety levels on the 19th day of pregnancy, which was reversed by finasteride, suggesting a role for alloP and alloTHDOC in the anxiolytic process. (c) 2006 Elsevier Inc. All rights reserved.en
dc.description.affiliationUFS, Dept Physiol, BR-49100000 Sao Cristovao, SE, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent569-574
dc.identifierhttp://dx.doi.org/10.1016/j.pbb.2006.10.011
dc.identifier.citationPharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 85, n. 3, p. 569-574, 2006.
dc.identifier.doi10.1016/j.pbb.2006.10.011
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29238
dc.identifier.wosWOS:000244122500011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectpregnancyen
dc.subjectanxietyen
dc.subjectfinasterideen
dc.subjectelevated plus-mazeen
dc.subjectneuroactive steroidsen
dc.subjectprogesteroneen
dc.titleThe anxiolytic effect of pregnancy in rats is reversed by finasterideen
dc.typeinfo:eu-repo/semantics/article
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