Genetic evidence for chromosome 4 loci influencing learning and memory

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dc.citation.volume131
dc.contributor.authorAnselmi, Mayara
dc.contributor.authorCorrea, Fernanda Junkes
dc.contributor.authorSantos, José Ronaldo dos
dc.contributor.authorSilva, Anatildes Feitosa
dc.contributor.authorCunha, João Antônio Sousa
dc.contributor.authorLeão, Anderson Henrique França Figueiredo [UNIFESP]
dc.contributor.authorCampelo, Clarissa Loureiro Chagas [UNIFESP]
dc.contributor.authorRibeiro, Alessandra Mussi [UNIFESP]
dc.contributor.authorSilva, Regina Helena [UNIFESP]
dc.contributor.authorIzídio, Geison Souza
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageSan Diego
dc.date.accessioned2020-07-22T13:22:58Z
dc.date.available2020-07-22T13:22:58Z
dc.date.issued2016
dc.description.abstractThe Lewis (LEW) and SHR (Spontaneously Hypertensive Rats) inbred rat strains differ in several anxiety/emotionality and learning/memory-related behaviors. We aimed to search quantitative trait locus (QTL) that influence these behaviors and confirm their effects in a congenic rat strain SLA16 (SHR.LEW.Anxrr16). LEW females and SHR males were intercrossed to produce F2 rats (96/sex), which were all tested in the plus-maze discriminative avoidance task (PMDAT), open-field (OF), object recognition (OR), spontaneous alternation (SA) and fear conditioning (FC). All animals were genotyped for microsatellite markers located on chromosome (Chr) 4. Behavioral and genotypic data were used to perform factor and QTL analyses. Also, to confirm the QTL effects, we tested male and female SLA16 rats and their isogenic control SHR in the same behavioral tests. A factor analysis of the F2 population revealed a correlation between anxiety/emotionality related behaviors and learning/memory in both sexes. QTL analysis revealed two significant QTL in males and three in females, on behavioral parameters in the PMDAT, OF and FC. Four QTL found herein were confirmed in SLA16 rats. The SLA16 strain displayed lower levels of anxiety/emotionality, higher locomotor activity and deficits in learning/memory in comparison with SHR strain. The Chr 4 contains genes influencing anxiety/emotionality and learning/memory behaviors and the SLA16 strain represents a valuable tool in the search for them. The use of the SLA16 strain as a genetic model for studying behavioral phenomena and their implications for psychiatric disorders are discussed. (C) 2016 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Santa Catarina, Dept Biol Celular Embriol & Genet, Lab Genet Comportamento, Florianopolis, SC, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Fisiol, Lab Estudo Memoria Roedores, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUniv Fed Sergipe, Dept Biociencias, Lab Neurociencias, Itabaiana, SE, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Farmacol, Lab Neurociencia Comportamental, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biociencias, Lab Neurociencias & Bioprospeccao Prod, Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Farmacol, Lab Neurociencia Comportamental, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biociencias, Lab Neurociencias & Bioprospeccao Prod, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipIDMCT/CNPq/CT-SAUDE: 57/2010pt
dc.description.sponsorshipIDMCT/CNPq: 14/2010pt
dc.description.sponsorshipIDMCTI/CNPq: 14/2013pt
dc.format.extent182-191
dc.identifierhttps://dx.doi.org/10.1016/j.nlm.2016.03.024
dc.identifier.citationNeurobiology Of Learning And Memory. San Diego, v. 131, p. 182-191, 2016.
dc.identifier.doi10.1016/j.nlm.2016.03.024
dc.identifier.issn1074-7427
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55964
dc.identifier.wosWOS:000376224900023
dc.language.isoeng
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofNeurobiology Of Learning And Memory
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnxietyen
dc.subjectADHDen
dc.subjectSHR ratsen
dc.subjectQTLen
dc.subjectCongenic strainen
dc.subjectFear conditioningen
dc.titleGenetic evidence for chromosome 4 loci influencing learning and memoryen
dc.typeinfo:eu-repo/semantics/article
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