Hormone profile in acute psychotic disorders: A cross-sectional comparison of serum hormone concentrations in treated and untreated male patients with schizophrenia

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dc.contributor.authorCosta, Anna Maria Niccolai [UNIFESP]
dc.contributor.authorLima, Mauricio Silva de [UNIFESP]
dc.contributor.authorTosta, Juliana
dc.contributor.authorRodrigues Filho, Salomao
dc.contributor.authorOliveira, Irismar Reis de
dc.contributor.authorSena, Eduardo Pone de
dc.contributor.authorMari, Jair de Jesus [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionBristol Myers Squibb Co
dc.contributor.institutionFed Univ Pelotas
dc.contributor.institutionEli Lilly Brazil
dc.contributor.institutionPax Clin Psiquiatrica
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.date.accessioned2016-01-24T12:41:24Z
dc.date.available2016-01-24T12:41:24Z
dc.date.issued2006-09-01
dc.description.abstractBackground: Antipsychotic drugs for the treatment of schizophrenia provide effective treatment of psychotic symptoms but might lead to neuroendocrine abnormalities.Objective: the aim of this study was to assess hypothalamic-pituitary-gonadal (HPG) axis function by comparing serum hormone profiles of newly admitted patients with psychotic disorders who were receiving antipsychotic drugs with those who were antipsychotic-drug-free during the preceding 6 months.Methods: Adult male patients admitted during a 1-year period (December 1999 to December 2000) to I of 2 Brazilian public psychiatric inpatient units that provide care for severely ill patients were eligible for this cross-sectional study if they had a diagnosis of schizophrenia based on the criteria given in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and a score > 24 on the Brief Psychiatric Rating Scale. On the morning after admission, serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), sex hormone-binding globulin (SHBG), prolactin, free testosterone (FT), and total testosterone (TT) were determined. A commercial laboratory provided the normal serum hormone concentrations of healthy Brazilian men in the same age range as that of the study patients.Results: Sixty-three adult male patients, aged 18 to 55, were included in the study. Forty-eight (76.2%) patients (mean [SD] age, 30.6 [8.9] years) were receiving antipsychotic drugs (treated). Fifteen (23.8%) patients (mean [SD] age, 36.5 [9.8] years) were antipsychotic-drug-free for 6 months before admission (untreated). the only significant between-group difference was for disease duration (treated, 7.6 [8.1] years vs untreated, 12.3 [9.7] years; P = 0.044). Treated patients were more likely to have higher dispersed serum hormone concentrations than the untreated patients. Serum concentration of FSH was numerically higher in the treated patients than in the untreated patients, although the difference was not statistically significant. Compared with the control group (1436 men and women for prolactin; 226 men for LH; 207 for FSH; 128 for TT; 128 for FT; and 128 for SHBG), patients in the treated group had significantly different mean [SD] serum concentrations of all hormones (treated vs control: prolactin, 24.3 [23.7] mu g/L vs 6.8 [0.12] mu g/L, P < 0.001; LH, 4.9 [3.4] U/L vs 3.3 [0.13] U/L, P = 0.001; FSH, 4.4 [3.9] U/L vs 3.0 [0.06] U/L, P = 0.025; TT, 17.5 [7.8] nmol/L vs 20.1 [1.64] nmol/L, P = 0.004; FT, 0.056 [0.08] nmol/L vs 0.06 [0.003] nmol/L, P < 0.001; and SHBG, 33.3 [18.9] nmol/L vs 48.4 [1.45] nmol/L, P = 0.002). Compared with the control group, patients in the untreated group had significantly different mean (SD) serum concentrations of all hormones except FSH and TT (untreated vs control: prolactin, 19.9 [12.8] mu g/L vs 6.8 [0.12] mu g/L, P = 0.001; LH, 6.0 [1.9] U/L vs 3.3 [0.13] U/L, P = 0.002; FT, 0.08 [0.04] nmol/L vs 0.06 [0.003] nmol/L, P = 0.001; and SHBG, 26.6 [11.6] nmol/L vs 48.4 [1.45] nmol/L, P < 0.001). No differences were found between the TT distribution curve of the control group and that of the untreated patients.Conclusion: This study supports further investigation of a potential difference in the HPG axis among treated and untreated patients with schizophrenia and those who do not have that condition.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationBristol Myers Squibb Co, São Paulo, Brazil
dc.description.affiliationFed Univ Pelotas, Dept Psychiat, Pelotas, Brazil
dc.description.affiliationEli Lilly Brazil, São Paulo, Brazil
dc.description.affiliationPax Clin Psiquiatrica, Goiania, Go, Brazil
dc.description.affiliationUniv Fed Bahia, Dept Psychiat & Neurol, Salvador, BA, Brazil
dc.description.affiliationUniv Fed Bahia, Dept Pharmacol, Salvador, BA, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent350-363
dc.identifierhttp://dx.doi.org/10.1016/j.curtheres.2006.10.003
dc.identifier.citationCurrent Therapeutic Research-clinical and Experimental. Bridgewater: Elsevier, v. 67, n. 5, p. 350-363, 2006.
dc.identifier.doi10.1016/j.curtheres.2006.10.003
dc.identifier.fileWOS000242356400005.pdf
dc.identifier.issn0011-393X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29095
dc.identifier.wosWOS:000242356400005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCurrent Therapeutic Research-clinical and Experimental
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectprolactinen
dc.subjecthormone profileen
dc.subjectschizophreniaen
dc.subjectpsychotic disordersen
dc.subjectantipsychoticsen
dc.titleHormone profile in acute psychotic disorders: A cross-sectional comparison of serum hormone concentrations in treated and untreated male patients with schizophreniaen
dc.typeinfo:eu-repo/semantics/article
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