High frequency of vitamin D receptor gene polymorphism FokI in Brazilian Type 1 diabetes mellitus patients with clinical autoimmune thyroid disease

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dc.citation.volume8
dc.contributor.authorMory, Denise Barreto [UNIFESP]
dc.contributor.authorLima Gabbay, Monica Andrade [UNIFESP]
dc.contributor.authorRocco, Eloa R. [UNIFESP]
dc.contributor.authorKasamatsu, Teresa [UNIFESP]
dc.contributor.authorCrispim, Felipe [UNIFESP]
dc.contributor.authorMiranda, Walquiria Lopes [UNIFESP]
dc.contributor.authorDib, Sergio Atala [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-08-21T16:59:48Z
dc.date.available2020-08-21T16:59:48Z
dc.date.issued2016
dc.description.abstractBackground: Polymorphisms of vitamin D receptor (VDR) gene have been studied as genetic markers of type 1 diabetes mellitus (T1DM) and some studies have reported associations with autoimmune thyroid disease. The aim of this study was to evaluate the relationship between VDR FokI polymorphism (rs10735810), thyroid autoimmunity and thyroid dysfunction (TD) in Brazilian T1DM. Methods: One-hundred-eighty T1DM patients were evaluated for age, duration of diabetes (DDM), positivity to TPO Antibody (TPOA), GAD Antibody (GADA), IA2 Antibody (IA2A) and fasting serum C-peptide (FCP) according to diagnosis of TD. PCR-RFLP analyses were carried out for VDR polymorphism FokI. Results: TPOA positivity (80.0 vs. 25.0 %, p < 0.001) and GADA positivity (56.0 vs. 30.3 %, p = 0.01) were higher in T1DM patients with TD with the same age and DDM than the group without TD, with no difference of FCP and IA2A positivity. We observed higher prevalence of VDR FokI in T1DM with TD (ff and Ff 73.9 % with TD vs. 52.7 % without TD, p = 0.05). Positivity to TPOA and presence of FokI polymorphism were significantly associated with the concurrence of TD in T1DM patients (OR 18.1; CI 3.7-87.0; p < 0.001). Conclusions: The VDR FokI polymorphism (rs10735810) was associated to persistence of GADA, TPOA positivity and TD in Brazilian T1DM. Positivity to TPOA and VDR polymorphism FokI were strongly associated with concurrence of T1D and TD. These data collaborate to understanding the joint susceptibility genes for TD in T1DM.en
dc.description.affiliationUniv Fed Sao Paulo, Div Endocrinol, Rua Botucatu,740 Vila Clementino, BR-04034970 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Endocrinol, Rua Botucatu,740 Vila Clementino, BR-04034970 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1186/s13098-016-0145-5
dc.identifier.citationDiabetology & Metabolic Syndrome. London, v. 8, p. -, 2016.
dc.identifier.doi10.1186/s13098-016-0145-5
dc.identifier.fileWOS000372569300004.pdf
dc.identifier.issn1758-5996
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57775
dc.identifier.wosWOS:000372569300004
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofDiabetology & Metabolic Syndrome
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectType 1 diabetesen
dc.subjectAutoimmune thyroid diseaseen
dc.subjectVitamin D receptor gene polymorphismen
dc.titleHigh frequency of vitamin D receptor gene polymorphism FokI in Brazilian Type 1 diabetes mellitus patients with clinical autoimmune thyroid diseaseen
dc.typeinfo:eu-repo/semantics/article
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