PRODH Polymorphisms, Cortical Volumes and Thickness in Schizophrenia

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dc.contributor.authorOta, Vanessa Kiyomi Arashiro [UNIFESP]
dc.contributor.authorBellucco, Fernanda Teixeira da Silva [UNIFESP]
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorSantoro, Marcos Leite [UNIFESP]
dc.contributor.authorNoto, Cristiano [UNIFESP]
dc.contributor.authorChristofolini, Denise Maria
dc.contributor.authorAssunção, Idaiane Batista de [UNIFESP]
dc.contributor.authorYamada, Karen M. [UNIFESP]
dc.contributor.authorRibeiro-dos-Santos, Andrea K.
dc.contributor.authorSantos, Sidney
dc.contributor.authorMari, Jair de Jesus [UNIFESP]
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.authorMelaragno, Maria I. [UNIFESP]
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorSato, Joao R. [UNIFESP]
dc.contributor.authorJackowski, Andrea Parolin [UNIFESP]
dc.contributor.authorBelangero, Sintia Iole [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFac Med ABC FMABC
dc.contributor.institutionFed Univ Para
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2016-01-24T14:35:18Z
dc.date.available2016-01-24T14:35:18Z
dc.date.issued2014-02-03
dc.description.abstractSchizophrenia is a neurodevelopmental disorder with high heritability. Several lines of evidence indicate that the PRODH gene may be related to the disorder. Therefore, our study investigates the effects of 12 polymorphisms of PRODH on schizophrenia and its phenotypes. To further evaluate the roles of the associated variants in the disorder, we have conducted magnetic resonance imaging (MRI) scans to assess cortical volumes and thicknesses. A total of 192 patients were evaluated using the Structured Clinical Interview for DSM-IV (SCID), Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale, Global Assessment of Functioning (GAF) and Clinical Global Impression (CGI) instruments. the study included 179 controls paired by age and gender. the samples were genotyped using the real-time polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP)-PCR and Sanger sequencing methods. A sample of 138 patients and 34 healthy controls underwent MRI scans. One polymorphism was associated with schizophrenia (rs2904552), with the G-allele more frequent in patients than in controls. This polymorphism is likely functional, as predicted by PolyPhen and SIFT, but it was not associated with brain morphology in our study. in summary, we report a functional PRODH variant associated with schizophrenia that may have a neurochemical impact, altering brain function, but is not responsible for the cortical reductions found in the disorder.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Disciplina Genet, Dept Morfol & Genet, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, LiNC, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Psiquiatria, São Paulo, Brazil
dc.description.affiliationFac Med ABC FMABC, Dept Ginecol & Obstet, Disciplina Genet & Reprod Humana, São Paulo, Brazil
dc.description.affiliationFed Univ Para, Lab Genet Humana & Med, BR-66059 Belem, Para, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Math Computat & Cognit, Santo Andre, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Disciplina Genet, Dept Morfol & Genet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, LiNC, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Psiquiatria, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2011/50740-5
dc.description.sponsorshipIDFAPESP: 2007/58736-1
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0087686
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 2, 6 p., 2014.
dc.identifier.doi10.1371/journal.pone.0087686
dc.identifier.fileWOS000330626900100.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37425
dc.identifier.wosWOS:000330626900100
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsAcesso aberto
dc.titlePRODH Polymorphisms, Cortical Volumes and Thickness in Schizophreniaen
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