Stevens-Johnson syndrome: The role of an ophthalmologist

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dc.citation.issue4
dc.citation.volume61
dc.contributor.authorJain, Rajat
dc.contributor.authorSharma, Namrata
dc.contributor.authorBasu, Sayan
dc.contributor.authorIyer, Geetha
dc.contributor.authorUeta, Mayumi
dc.contributor.authorSotozono, Chie
dc.contributor.authorKannabiran, Chitra
dc.contributor.authorRathi, Varsha M.
dc.contributor.authorGupta, Nidhi
dc.contributor.authorKinoshita, Shigeru
dc.contributor.authorGomes, Jose A. P. [UNIFESP]
dc.contributor.authorChodosh, James
dc.contributor.authorSangwan, Virender S.
dc.coverageNew York
dc.date.accessioned2020-08-14T13:44:29Z
dc.date.available2020-08-14T13:44:29Z
dc.date.issued2016
dc.description.abstractStevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes. Acute SJS leads to the acute inflammation of the ocular surface and chronic conjunctivitis. If not properly treated, it causes chronic cicatricial conjunctivitis and cicatricial lid margin abnormalities. Persistent inflammation and ulceration of the ocular surface with cicatricial complications of the lids leads to chronic ocular sequelae, ocular surface damage, and corneal scarring. The destruction of the glands that secrete the tear film leads to a severe form of dry eye that makes the management of chronic SJS difficult. The option that is routinely used for corneal visual rehabilitation, keratoplasty, is best avoided in such cases. We describe the management strategies that are most effective during the acute and chronic stages of SJS. Although treatments for acute SJS involve immunosuppressive and immunomodulatory therapies, amniotic membrane transplantation is also useful. The options for visual rehabilitation in patients with chronic SJS are undergoing radical change. We describe the existing literature regarding the management of SJS and highlight recent advances in the management of this disorder. (C) 2016 Elsevier Inc. All rights reserved.en
dc.description.affiliationDrishtiCONE Eye Care, Dept Ophthalmol, Cornea Segment Serv, New Delhi, India
dc.description.affiliationDrishtiCONE Eye Care, Dept Ophthalmol, Ocular Surface Segment Serv, New Delhi, India
dc.description.affiliationDrishtiCONE Eye Care, Dept Ophthalmol, Anterior Segment Serv, New Delhi, India
dc.description.affiliationAll India Inst Med Sci, Dr Rajendra Prasad Ctr Ophthalm Sci, Cornea Surg Serv, New Delhi 110029, India
dc.description.affiliationAll India Inst Med Sci, Dr Rajendra Prasad Ctr Ophthalm Sci, Refract Surg Serv, New Delhi 110029, India
dc.description.affiliationLV Prasad Eye Inst, Dept Ophthalmol, Cornea Segment Serv, Hyderabad, Telangana, India
dc.description.affiliationLV Prasad Eye Inst, Dept Ophthalmol, Anterior Segment Serv, Hyderabad, Telangana, India
dc.description.affiliationSankara Nethralaya, Dr G Sitalakshmi Mem Clin Ocular Surface Disorder, Dept Ophthalmol, CJ Shah Cornea Serv, Chennai, Tamil Nadu, India
dc.description.affiliationKyoto Prefectural Univ Med, Dept Ophthalmol, Kyoto, Japan
dc.description.affiliationDoshisha Univ, Dept Ophthalmol, Kyotanabe, Japan
dc.description.affiliationLVPEI, Kallam Anji Reddy Mol Genet Lab, Dept Ophthalmol, Hyderabad, Telangana, India
dc.description.affiliationLV Prasad Eye Inst, Dept Ophthalmol, Cornea Serv, Hyderabad, Telangana, India
dc.description.affiliationDr Shroff Char Eye Hosp, Dept Ophthalmol, Delhi, India
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med UNIFESP EPM, Dept Ophthalmol, Cornea & External Dis Serv, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med UNIFESP EPM, Dept Ophthalmol, CASO, Sao Paulo, Brazil
dc.description.affiliationHarvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol, Boston, MA USA
dc.description.affiliationLV Prasad Eye Inst, Srujana Ctr Innovat, Dept Ophthalmol, Hyderabad, Telangana, India
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med UNIFESP EPM, Dept Ophthalmol, Cornea & External Dis Serv, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med UNIFESP EPM, Dept Ophthalmol, CASO, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent369-399
dc.identifierhttp://dx.doi.org/10.1016/j.survophthal.2016.01.004
dc.identifier.citationSurvey Of Ophthalmology. New York, v. 61, n. 4, p. 369-399, 2016.
dc.identifier.doi10.1016/j.survophthal.2016.01.004
dc.identifier.issn0039-6257
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57696
dc.identifier.wosWOS:000378444500001
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofSurvey Of Ophthalmology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectStevens-Johnson syndromeen
dc.subjectacuteen
dc.subjectdry eyeen
dc.subjectkeratoprosthesisen
dc.subjectstem cell transplantation: PROSEen
dc.titleStevens-Johnson syndrome: The role of an ophthalmologisten
dc.typeinfo:eu-repo/semantics/article
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