Expression of human papillomavirus e6 and e7 oncoprotein mrna in women with low-grade squamous intraepithelial lesions or less

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dc.contributor.authorCasagrande, D. C. [UNIFESP]
dc.contributor.authorRibalta, J. C. L. [UNIFESP]
dc.contributor.authorLeite, K. D. P. F. [UNIFESP]
dc.contributor.authorSchimidt, M. [UNIFESP]
dc.contributor.authorSpeck, N. M. D. G. [UNIFESP]
dc.date.accessioned2019-01-21T10:30:03Z
dc.date.available2019-01-21T10:30:03Z
dc.date.issued2016
dc.description.abstractWe verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. To investigate the relationship between mRNA expression and viral infection type, we assessed genotyping in single infections. Samples from 825 women were submitted to the E6/E7 survey. We noticed a larger percentage of E6/E7 mRNA expression in the atypical squamous cells of undetermined significance (ASC-US) and LSIL cytologies. Negative results of mRNA expression were in accordance with negative cytologies. In positive cases, the infection by a single HPV type was most common, with type 16 being most prevalent. The expression of mRNA was most prevalent in ASC-US and LSIL cytologies, compared with the negative cytology. The infection by a HPV type was more frequent in cases of positive expression, with HPV type 16 being found most frequently. Patients with LSIL cytologies had a higher percentage of multiple infections.en
dc.description.affiliationNúcleo de Prevenção de Doenças Ginecológicas, Departamento de Ginecologia, Escola Paulista de Medicina, São Paulo, SP, Brasil
dc.description.affiliationDepartamento de Patologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.affiliationLaboratório Salomão & Zoppi Diagnósticos, São Paulo, SP, Brasil
dc.description.affiliationUnifespNúcleo de Prevenção de Doenças Ginecológicas, Departamento de Ginecologia, Escola Paulista de Medicina, São Paulo, SP, Brasil
dc.description.affiliationUnifespDepartamento de Patologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.format.extentUNSP gmr.15017916
dc.identifierhttp://dx.doi.org/10.4238/gmr.15017916
dc.identifier.citationGenetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017916, 2016.
dc.identifier.doi10.4238/gmr.15017916
dc.identifier.issn1676-5680
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49552
dc.identifier.wosWOS:000373880400085
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics And Molecular Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectE6/E7 Mrnaen
dc.subjectHuman Papillomavirusen
dc.subjectNegative Cytologyen
dc.subjectAsc-Us Cytologyen
dc.subjectLsil CytologyPretect Hpv-Prooferen
dc.subjectDna-Positive Womenen
dc.subjectCervical-Canceren
dc.subjectGenotype Distributionen
dc.subjectNatural-Historyen
dc.subjectYoung-Womenen
dc.subjectFollow-Upen
dc.subjectNeoplasiaen
dc.subjectRisken
dc.subjectPersistenceen
dc.titleExpression of human papillomavirus e6 and e7 oncoprotein mrna in women with low-grade squamous intraepithelial lesions or lessen
dc.typeinfo:eu-repo/semantics/article
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