Green Tea Extract Supplementation Induces the Lipolytic Pathway, Attenuates Obesity, and Reduces Low-Grade Inflammation in Mice Fed a High-Fat Diet

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dc.contributor.authorCunha, Claudio Alexandre [UNIFESP]
dc.contributor.authorLira, Fabio Santos de
dc.contributor.authorRosa Neto, José Cesar [UNIFESP]
dc.contributor.authorPimentel, Gustavo Duarte
dc.contributor.authorSouza, Gabriel Inacio Honorato de [UNIFESP]
dc.contributor.authorSilva, Camila Morais Goncalves da
dc.contributor.authorSouza, Claudio Teodoro de
dc.contributor.authorRibeiro, Eliane Beraldi [UNIFESP]
dc.contributor.authorSawaya, Alexandra Christine Helena Frankland
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorRodrigues, Bruno
dc.contributor.authorCarvalho, Patricia de Oliveira
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv So Santa Catarina
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionSao Francisco Univ USF
dc.contributor.institutionUniv Sao Judas Tadeu
dc.date.accessioned2016-01-24T14:30:54Z
dc.date.available2016-01-24T14:30:54Z
dc.date.issued2013-01-01
dc.description.abstractThe aim of this study was to evaluate the effects of green tea Camellia sinensis extract on proinflammatory molecules and lipolytic protein levels in adipose tissue of diet-induced obese mice. Animals were randomized into four groups: CW (chow diet and water); CG (chow diet and water + green tea extract); HW (high-fat diet and water); HG (high-fat diet and water + green tea extract). the mice were fed ad libitum with chow or high-fat diet and concomitantly supplemented (oral gavage) with 400 mg/kg bodyweight/day of green tea extract (CG and HG, resp.). the treatments were performed for eight weeks. UPLC showed that in 10 mg/mL green tea extract, there were 15 mu g/mg epigallocatechin, 95 mu g/mg epigallocatechin gallate, 20.8 mu g/mg epicatechin gallate, and 4.9 mu g/mg gallocatechin gallate. Green tea administered concomitantly with a high-fat diet increased HSL, ABHD5, and perilipin in mesenteric adipose tissue, and this was associated with reduced body weight and adipose tissue gain. Further, we observed that green tea supplementation reduced inflammatory cytokine TNF alpha levels, as well as TLR4, MYD88, and TRAF6 proinflammatory signalling. Our results show that green tea increases the lipolytic pathway and reduces adipose tissue, and this may explain the attenuation of low-grade inflammation in obese mice.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Fisiol, Disciplina Fisiol Nutr, BR-04023060 São Paulo, Brazil
dc.description.affiliationUniv So Santa Catarina, Hlth Sci Unit, Lab Exercise Biochem & Physiol, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Internal Med, BR-13083887 Campinas, SP, Brazil
dc.description.affiliationSao Francisco Univ USF, Lab Multidisciplinary Res, BR-12916900 Braganca Paulista, SP, Brazil
dc.description.affiliationState Univ Campinas UNICAMP, Inst Biol, Dept Plant Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Sao Judas Tadeu, Human Moviment Lab, BR-05503001 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Fisiol, Disciplina Fisiol Nutr, BR-04023060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent8
dc.identifierhttps://dx.doi.org/10.1155/2013/635470
dc.identifier.citationMediators of Inflammation. New York: Hindawi Publishing Corporation, 8 p., 2013.
dc.identifier.doi10.1155/2013/635470
dc.identifier.fileWOS000314585200001.pdf
dc.identifier.issn0962-9351
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/35703
dc.identifier.wosWOS:000314585200001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofMediators of Inflammation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleGreen Tea Extract Supplementation Induces the Lipolytic Pathway, Attenuates Obesity, and Reduces Low-Grade Inflammation in Mice Fed a High-Fat Dieten
dc.typeinfo:eu-repo/semantics/article
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