The catechol-O-methyltransferase (COMT) gene polymorphism and prevalence of uterine fibroids

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dc.contributor.authorOliveira, Emerson de [UNIFESP]
dc.contributor.authorCastro, Rodrigo de Aquino [UNIFESP]
dc.contributor.authorVieira Gomes, Mariano Tamura [UNIFESP]
dc.contributor.authorCotrim Guerreiro da Silva, Ismael Dale [UNIFESP]
dc.contributor.authorBaracat, Edmund Chada [UNIFESP]
dc.contributor.authorLima, Geraldo Rodrigues de [UNIFESP]
dc.contributor.authorFerreira Sartori, Marair Gracio [UNIFESP]
dc.contributor.authorBatista Castello Girao, Manoel Joao [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:29Z
dc.date.available2016-01-24T13:51:29Z
dc.date.issued2008-07-01
dc.description.abstractObjective: To assess the possible association between the catechol-O-methyltransferase (COMT) polymorphism and uterine fibroids in Brazilian women.Design: Case-control study.Patient(s): One hundred twenty-four premenopausal women with fibroids, and 193 postmenopausal controls not presenting the disease.Intervention(s): the subjects were classified as white or non-white (black and mulatto), and COMT genotypes were determined. DNA was extracted from the uterus of cases and from peripheral blood of controls and submitted to polymerase chain reaction (PCR) and agarose gel electrophoresis.Main outcome measure(s): the presence of the COMT polymorphism was recorded for all patients, and the frequency and distribution among cases and controls were compared according to race. Binomial log regression models were used to estimate odds-ratios (OR) for uterine volumes of <290 cm(3) (small fibroids) vs. those >290 cm(3) (large fibroids). Potential confounding variables (age, race and parity) were added to the model.Results: Genotypes positive for the COMT polymorphism (heterozygous or mutant homozygous) were found in 45% of white and 28.9% of non-white women (p =.013) and the polymorphic allele frequencies in these groups were 27.2% and 16.3%, respectively (p=.006). However, there were no clear differences between patients and controls within the white subgroup with regard to the presence of COMT polymorphism-containing genotypes (41.5% vs. 46.0%, respectively) (p =.60), or for the polymorphic allele frequency (26.8% vs. 27.3%, respectively) (p =.92). for non-white women, there were also no differences between cases and controls for the frequency of polymorphic genotypes (28.9% vs. 28.9%, respectively) (p =.995), or for the polymorphic allele frequency (17.8 vs. 14.5, respectively) (p =.565).Estimated OR for small or large fibroids in association with the polymorphic allele revealed a positive association between the allele with lower activity and large fibroids (vs. small) (OR = 3.3; 95% confidence interval [CI] = 1.31-8.46). the adjusted OR was 4.35 (95% confidence interval [CI] = 1.58-11.9).Conclusions: the catechol-O-methyltransferase polymorphism is a risk factor for the development of large uterine fibroids in Brazilian women suffering from fibroids. (C) 2008 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Gynecol, BR-04062500 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Gynecol, BR-04062500 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 03/04533-1
dc.format.extent235-238
dc.identifierhttp://dx.doi.org/10.1016/j.maturitas.2008.07.001
dc.identifier.citationMaturitas. Clare: Elsevier B.V., v. 60, n. 3-4, p. 235-238, 2008.
dc.identifier.doi10.1016/j.maturitas.2008.07.001
dc.identifier.issn0378-5122
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30741
dc.identifier.wosWOS:000260640900007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMaturitas
dc.rightsAcesso aberto
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectUterine fibroidsen
dc.subjectUterine leiomyomaen
dc.subjectRisk factorsen
dc.subjectCatechol-O-methyltransferaseen
dc.subjectPolymorphismen
dc.titleThe catechol-O-methyltransferase (COMT) gene polymorphism and prevalence of uterine fibroidsen
dc.typeArtigo
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